Transcription Factor

						

			
Accessions: O75840 (JASPAR 2024)

			
Names: KLF7_HUMAN, Krueppel-like factor 7, Ubiquitous krueppel-like factor
Organisms: Homo sapiens
Libraries: JASPAR 2024 1
1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 302
Pfam Domains:   219-243 Zinc finger, C2H2 type
  219-243 C2H2-type zinc finger
  235-256 Zinc-finger double domain
  249-273 Zinc finger, C2H2 type
  249-273 C2H2-type zinc finger
  266-289 Zinc-finger double domain
  279-301 Zinc finger, C2H2 type
  279-301 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 MDVLASYSIFQELQLVHDTGYFSALPSLEETWQQTCLELERYLQTEPRRISETFGEDLDC   60
  61 FLHASPPPCIEESFRRLDPLLLPVEAAICEKSSAVDILLSRDKLLSETCLSLQPASSSLD  120
 121 SYTAVNQAQLNAVTSLTPPSSPELSRHLVKTSQTLSAVDGTVTLKLVAKKAALSSVKVGG  180
 181 VATAAAAVTAAGAVKSGQSDSDQGGLGAEACPENKKRVHRCQFNGCRKVYTKSSHLKAHQ  240
 241 RTHTGEKPYKCSWEGCEWRFARSDELTRHYRKHTGAKPFKCNHCDRCFSRSDHLALHMKR  300
 301 HI
Interface Residues: 231, 232, 233, 234, 235, 237, 238, 240, 241, 244, 260, 261, 262, 263, 264, 265, 267, 268, 269, 272, 289, 290, 291, 292, 293, 294, 296, 297, 300
3D-footprint Homologues: 6jnm_A, 6ml4_A, 5v3j_F, 3uk3_C, 1tf3_A, 7n5w_A, 2gli_A, 5kl3_A, 1tf6_A, 5ei9_F, 1g2f_F, 7ysf_A, 1ubd_C, 6blw_A, 2kmk_A, 6u9q_A, 8h9h_G, 7y3m_I, 6e94_A, 5kkq_D, 2lt7_A, 6a57_A, 2jpa_A, 5k5i_A, 7w1m_H, 8cuc_F, 4m9v_C, 7y3l_A, 4x9j_A, 1f2i_J, 2wbs_A, 7txc_E, 8ssq_A, 1llm_D, 5yel_A, 2drp_D, 8gn3_A, 5yj3_D
Binding Motifs: MA1959.1 dGGGCGKgG
MA1959.2 GGGCGKgG
			
Publications: Klein RH, Hu W, Kashgari G, Lin Z, Nguyen T, Doan M, Andersen B. Characterization of enhancers and the role of the transcription factor KLF7 in regulating corneal epithelial differentiation. J Biol Chem 292:18937-18950 (2017). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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