Transcription Factor
| Accessions: | Q2M3X9 (JASPAR 2024) |
| Names: | ZN674_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q2M3X9 |
| Length: | 581 |
| Pfam Domains: | 8-48 KRAB box 210-233 Zinc-finger double domain 223-246 C2H2-type zinc finger 224-246 C2H2-type zinc finger 224-246 Zinc finger, C2H2 type 238-262 Zinc-finger double domain 252-274 C2H2-type zinc finger 252-274 Zinc finger, C2H2 type 252-274 C2H2-type zinc finger 269-289 Zinc-finger double domain 279-302 C2H2-type zinc finger 280-302 C2H2-type zinc finger 280-302 Zinc finger, C2H2 type 295-319 Zinc-finger double domain 308-330 C2H2-type zinc finger 308-330 Zinc finger, C2H2 type 373-394 Zinc-finger double domain 384-395 C2H2-type zinc finger 385-407 C2H2-type zinc finger 385-407 Zinc finger, C2H2 type 399-423 Zinc-finger double domain 412-424 C2H2-type zinc finger 413-435 C2H2-type zinc finger 413-435 Zinc finger, C2H2 type 427-451 Zinc-finger double domain 440-463 C2H2-type zinc finger 441-463 C2H2-type zinc finger 441-463 Zinc finger, C2H2 type 458-479 Zinc-finger double domain 468-481 C2H2-type zinc finger 469-491 Zinc finger, C2H2 type 469-491 C2H2-type zinc finger 486-508 Zinc-finger double domain 496-517 C2H2-type zinc finger 497-519 C2H2-type zinc finger 497-519 Zinc finger, C2H2 type 512-535 Zinc-finger double domain 524-545 C2H2-type zinc finger 525-547 Zinc finger, C2H2 type 542-563 Zinc-finger double domain 552-575 C2H2-type zinc finger 553-575 C2H2-type zinc finger 553-575 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MAMSQESLTFKDVFVDFTLEEWQQLDSAQKNLYRDVMLENYSHLVSVGHLVGKPDVIFRL 60 61 GPGDESWMADGGTPVRTCAGEDRPEVWEVDEQIDHYKESQDKFLWQAAFIGKETLKDESG 120 121 QECKICRKIIYLNTDFVSVKQRLPKYYSWERCSKHHLNFLGQNRSYVRKKDDGCKAYWKV 180 181 CLHYNLHKAQPAERFFDPNQRGKALHQKQALRKSQRSQTGEKLYKCTECGKVFIQKANLV 240 241 VHQRTHTGEKPYECCECAKAFSQKSTLIAHQRTHTGEKPYECSECGKTFIQKSTLIKHQR 300 301 THTGEKPFVCDKCPKAFKSSYHLIRHEKTHIRQAFYKGIKCTTSSLIYQRIHTSEKPQCS 360 361 EHGKASDEKPSPTKHWRTHTKENIYECSKCGKSFRGKSHLSVHQRIHTGEKPYECSICGK 420 421 TFSGKSHLSVHHRTHTGEKPYECRRCGKAFGEKSTLIVHQRMHTGEKPYKCNECGKAFSE 480 481 KSPLIKHQRIHTGERPYECTDCKKAFSRKSTLIKHQRIHTGEKPYKCSECGKAFSVKSTL 540 541 IVHHRTHTGEKPYECRDCGKAFSGKSTLIKHQRSHTGDKNL |
| Interface Residues: | 225, 235, 236, 237, 238, 240, 241, 262, 263, 265, 266, 269, 290, 291, 292, 293, 294, 296, 297, 318, 319, 320, 321, 322, 325, 336, 368, 369, 370, 371, 374, 395, 396, 398, 399, 402, 413, 423, 424, 425, 426, 427, 428, 430, 434, 451, 452, 453, 454, 455, 457, 458, 461, 462, 479, 480, 481, 482, 483, 485, 486, 487, 488, 489, 492, 506, 508, 510, 511, 512, 513, 514, 515, 517, 518, 535, 536, 537, 538, 539, 540, 541, 542, 563, 564, 565, 566, 567, 569, 570 |
| 3D-footprint Homologues: | 4wcg_A, 2drp_D, 1tf3_A, 7w1m_H, 4x9j_A, 1g2f_F, 2wbs_A, 5v3j_F, 8ssq_A, 8ssu_A, 8cuc_F, 7y3l_A, 8gn3_A, 7y3m_I, 2kmk_A, 3uk3_C, 7n5w_A, 6ml4_A, 1llm_D, 8h9h_G, 7ysf_A, 5yel_A, 5k5l_F, 1tf6_A, 6u9q_A, 5kkq_D, 5yj3_D, 7txc_E, 6e94_A, 1ubd_C, 6jnm_A, 2gli_A, 6blw_A, 5ei9_F, 5k5i_A, 4m9v_C, 6a57_A, 2jpa_A, 1f2i_J, 5kl3_A, 2lt7_A |
| Binding Motifs: | UN0648.1 ggGGCAAyAAAaba UN0648.2 ggGGCAAyAAAa |
| Binding Sites: | UN0648.1.1 UN0648.1.10 / UN0648.1.17 UN0648.1.11 / UN0648.1.18 UN0648.1.12 UN0648.1.13 UN0648.1.14 UN0648.1.15 UN0648.1.16 UN0648.1.17 UN0648.1.18 UN0648.1.19 UN0648.1.2 UN0648.1.20 UN0648.1.3 UN0648.1.4 UN0648.1.5 / UN0648.1.6 UN0648.1.6 / UN0648.1.8 UN0648.1.10 / UN0648.1.7 UN0648.1.12 / UN0648.1.8 UN0648.1.16 / UN0648.1.9 UN0648.1.11 UN0648.1.13 UN0648.1.14 UN0648.1.15 UN0648.1.19 UN0648.1.20 UN0648.1.5 UN0648.1.7 UN0648.1.9 UN0648.2.1 UN0648.2.10 UN0648.2.11 UN0648.2.12 UN0648.2.13 UN0648.2.14 UN0648.2.15 / UN0648.2.20 UN0648.2.16 UN0648.2.17 UN0648.2.18 / UN0648.2.8 UN0648.2.19 UN0648.2.2 UN0648.2.3 UN0648.2.4 UN0648.2.5 UN0648.2.6 UN0648.2.7 UN0648.2.9 |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.