Transcription Factor

						

			
Accessions: 6pst_L (3D-footprint 20231221)

			
Names: RNA polymerase sigma factor RpoD, RPOD_ECOLI, Sigma-70
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P00579
Length: 558
Pfam Domains:      2-74 Sigma-70 factor, region 1.1
   89-120 Sigma-70 factor, region 1.2
  131-161 Sigma-70, non-essential region
  162-293 Sigma-70, non-essential region
  324-394 Sigma-70 region 2 
  403-479 Sigma-70 region 3
  492-545 Sigma-70, region 4
Sequence: 
(in bold interface residues)		   1 SQLKLLVTRGKEQGYLTYAEVNDHLPEDIVDSDQIEDIIQMINDMGIQVMEEAPDADDLM   60
  61 LAENTADEDAAEAAAQVLSSVESEIGRTTDPVRMYMREMGTVELLTREGEIDIAKRIEDG  120
 121 INQVQCSVAEYPEAITYLLEQYDRVEAEEARLSDLITGFVDIDPELAREKFAELRAQYVV  180
 181 TRDTIKHATAQEEILKLSEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCVEQC  240
 241 KMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHDVSEEVHRALQKLQQIEEETGLTI  300
 301 EQVKDINRRMSIGEAKARRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGLMKA  360
 361 VDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRIPVHMIETINKLNRISRQMLQEMG  420
 421 REPTPEELAERMLMPEDKIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPLDSA  480
 481 TTESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYTLEEVGKQFDVTRERIRQIEAKAL  540
 541 RKLRHPSRSEVLRSFLDD
Interface Residues: 197, 207, 209, 210, 212, 213, 518, 519, 528, 529, 530, 531, 533, 534
3D-footprint Homologues: 3h0d_A, 6ido_B, 3n97_A, 8cyf_B
Binding Motifs: 6pst_L GATGCGCCnnTnnnnnnnnnnnnnGTCAAT
Binding Sites: 6pst_O
6pst_P
			
Publications: Chen J, Chiu C, Gopalkrishnan S, Chen AY, Olinares PDB, Saecker RM, Winkelman JT, Maloney MF, Chait BT, Ross W, Gourse RL, Campbell EA, Darst SA. Stepwise Promoter Melting by Bacterial RNA Polymerase. Mol Cell 78:275-288 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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