Transcription Factor
| Accessions: | ERG_DBD (HumanTF 1.0), ERG_TF1 (HumanTF2 1.0), ERG_TF2 (HumanTF2 1.0) |
| Names: | ERG, ERG_HUMAN, Transcriptional regulator ERG, Transforming protein ERG, Eag homolog, Eag-related protein 1, ERG-1, Ether-a-go-go-related gene potassium channel 1, Ether-a-go-go-related protein 1, H-ERG, hERG-1, hERG1, KCNH2_HUMAN, Potassium voltage-gated channel subfamily H member 2, Voltage-gated potassium channel subunit Kv11.1 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P11308 |
| Notes: | Ensembl ID: ENSG00000157554; DNA-binding domain sequence; TF family: ETS; Clone source: MGC, Ensembl ID: ENSG00000157554; Construct type: TF1(SBP); TF family: ETS; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000157554; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 302 |
| Pfam Domains: | 22-104 Sterile alpha motif (SAM)/Pointed domain 193-275 Ets-domain |
| Sequence: (in bold interface residues) | 1 MASPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLP 60 61 DVNILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQ 120 121 NSPRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILG 180 181 PTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK 240 241 PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPY 300 301 MG |
| Interface Residues: | 191, 246, 247, 249, 250, 251, 253, 254, 268 |
| 3D-footprint Homologues: | 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B |
| Binding Motifs: | ERG_DBD_1 ACCGGAArTg ERG_DBD_2 aCCGGAwATCCGgt GCM1_ERG rTGCGGGCGGaarkg TEAD4_ERG_1 ACCGGAAATrCc TEAD4_ERG_2 aCCGGAArTrvawgrcATwCC TEAD4_ERG_2_3 rCCGGAAATrCC |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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