Transcription Factor

						

			
Accessions: REL_HUMAN (HOCOMOCO 10), Q04864 (JASPAR 2024)

			
Names: REL_HUMAN
Organisms: Homo sapiens
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]

2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 619
Pfam Domains:    10-178 Rel homology domain (RHD)
Sequence: 
(in bold interface residues)		   1 MASGAYNPYIEIIEQPRQRGMRFRYKCEGRSAGSIPGEHSTDNNRTYPSIQIMNYYGKGK   60
  61 VRITLVTKNDPYKPHPHDLVGKDCRDGYYEAEFGQERRPLFFQNLGIRCVKKKEVKEAII  120
 121 TRIKAGINPFNVPEKQLNDIEDCDLNVVRLCFQVFLPDEHGNLTTALPPVVSNPIYDNRA  180
 181 PNTAELRICRVNKNCGSVRGGDEIFLLCDKVQKDDIEVRFVLNDWEAKGIFSQADVHRQV  240
 241 AIVFKTPPYCKAITEPVTVKMQLRRPSDQEVSESMDFRYLPDEKDTYGNKAKKQKTTLLF  300
 301 QKLCQDHVETGFRHVDQDGLELLTSGDPPTLASQSAGITVNFPERPRPGLLGSIGEGRYF  360
 361 KKEPNLFSHDAVVREMPTGVSSQAESYYPSPGPISSGLSHHASMAPLPSSSWSSVAHPTP  420
 421 RSGNTNPLSSFSTRTLPSNSQGIPPFLRIPVGNDLNASNACIYNNADDIVGMEASSMPSA  480
 481 DLYGISDPNMLSNCSVNMMTTSSDSMGETDNPRLLSMNLENPSCNSVLDPRDLRQLHQMS  540
 541 SSSMSAGANSNTTVFVSQSDAFEGSDFSCADNSMINESGPSNSTNPNSHGFVQDSQYSGI  600
 601 GSMQNEQLSDSFPYEFFQV
Interface Residues: 22, 24, 25, 27, 28, 30, 31, 32, 179, 181, 210, 238
3D-footprint Homologues: 1gji_A, 2ram_A, 1imh_C, 7cli_B, 1nfk_A, 1a3q_A, 2o61_A
Binding Motifs: REL_HUMAN.H10MO.C|M01479 dkGGrmwTTCCm
MA0101.1 sGGrmwTTCC
Binding Sites: MA0101.1.1
MA0101.1.10
MA0101.1.11
MA0101.1.12
MA0101.1.13
MA0101.1.14
MA0101.1.15
MA0101.1.16
MA0101.1.17
MA0101.1.2
MA0101.1.3
MA0101.1.4
MA0101.1.5
MA0101.1.6
MA0101.1.7
MA0101.1.8
MA0101.1.9
			
Publications: Kunsch C., Ruben S. M., Rosen C. A. Selection of optimal kappaB/Rel DNA-binding motifs: interaction of both subunits of NF-kappaB with DNA is required for transcriptional activation. Mol. Cell. Biol. 12:4412-4421 (1992). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.