Transcription Factor

Accessions: UP00269A (UniPROBE 20160601)
Names: Protein RDR1, Rdr1, Repressor of drug resistance protein 1, YOR380W
Organisms: Saccharomyces cerevisiae
Libraries: UniPROBE 20160601 1
1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed]
Uniprot: Q08904
Description: Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins
Length: 105
Pfam Domains: 17-49 Fungal Zn(2)-Cys(6) binuclear cluster domain
Sequence:
(in bold interface residues)
1 ASPGSTALPHKRQRVRKACVPCRERKRKCNGKSPCEMCVAYGYVCHYIDGRVPSASPQVQ 60
61 QVGETSPDTESRPFVLPGIHRNEQPQPINTQNVTSQNIVDPTKSR
Interface Residues: 12, 13, 23, 25, 26, 27, 28, 40, 41, 50, 52, 53
3D-footprint Homologues: 1f5e_P, 1hwt_C, 6o19_A, 1zme_D, 7uik_T, 1d66_B, 3coq_A, 6gys_C
Binding Motifs: UP00269A_1 tsvkmmstGCGGAwAtsrmks
Binding Sites: ACCCGCGG
AGCGGATA
ATATCCGC
ATCCGCAA
ATCCGCAC
ATCCGCGG
ATCCGGAT
ATTCCGCA
CATCCGCA
CCGCGGAA
CGCGCGGA
CGCGGATA
CTTCCGCA
GCGGATAC
GTGCGGAA
GTTCCGCA
TATCCGCA
TCCGCGGA
TTCCGCAA
CCCGCGGA
Publications: *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed]
Related annotations: PaperBLAST

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