Transcription Factor

						

			
Accessions: 1f2i_G (3D-footprint 20231221), 1f2i_H (3D-footprint 20231221), 1f2i_I (3D-footprint 20231221), 1f2i_J (3D-footprint 20231221), 1f2i_L (3D-footprint 20231221)

			
Names: Early growth response protein 1, EGR-1, EGR1_MOUSE, FUSION OF N-TERMINAL 17-MER PEPTIDE EXTENSION TO ZIF12, Nerve growth factor-induced protein A, NGFI-A, Transcription factor Zif268, Zinc finger protein Krox-24
Organisms: Mus musculus
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P08046
Length: 66
Pfam Domains:     13-37 Zinc finger, C2H2 type
    13-37 C2H2-type zinc finger
    30-53 Zinc-finger double domain
    43-65 C2H2-type zinc finger
    43-65 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 NLLNYVVPKMRPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTT   60
  61 HIRTHT
Interface Residues: 1, 24, 25, 26, 27, 28, 29, 31, 32, 33, 53, 54, 55, 56, 57, 58, 59, 60, 61, 64
3D-footprint Homologues: 6wmi_A, 8gn3_A, 7n5w_A, 3uk3_C, 7ysf_A, 2kmk_A, 1tf3_A, 6jnm_A, 8cuc_F, 7y3l_A, 5v3j_F, 4x9j_A, 2i13_A, 1llm_D, 6blw_A, 5kkq_D, 2wbs_A, 1ubd_C, 6u9q_A, 5ei9_F, 2jpa_A, 1mey_C, 7txc_E, 5kl3_A, 2drp_D, 1f2i_J, 5k5i_A, 8ssq_A, 7w1m_H, 5und_A, 2gli_A, 1g2f_F, 5k5l_F, 2lt7_A, 8ssu_A, 1tf6_A, 6ml4_A, 8h9h_G, 4m9v_C, 7eyi_G, 7y3m_I, 6e94_A, 6a57_A, 5yel_A, 5yj3_D
Binding Motifs: 1f2i_GH tGGGCGCGCCCa
1f2i_IJ TGGGCGCGCCCa
1f2i_J CGCCCa
1f2i_KL tGGGCGCGCCCa
Binding Sites: 1f2i_A / 1f2i_B / 1f2i_C / 1f2i_D / 1f2i_E / 1f2i_F
			
Publications: Wang B.S, Grant R.A, Pabo C.O. Selected peptide extension contacts hydrophobic patch on neighboring zinc finger and mediates dimerization on DNA. Nature structural biology 8:589-93 (2001). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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