Transcription Factor

						

			
Accessions: RARA_full (HumanTF 1.0)

			
Names: PML-RARA-regulated adapter molecule 1, PRAM_HUMAN, PRAM-1, RARA
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Uniprot: Q96QH2
Notes: Ensembl ID: ENSG00000131759; Full protein sequence; TF family: Nuclear_Receptor; Clone source: Megaman
Length: 634
Pfam Domains:    82-150 Zinc finger, C4 type (two domains)
  227-387 Ligand-binding domain of nuclear hormone receptor
Sequence: 
(in bold interface residues)		   1 MYESVEVGGPTPNPFLVVDFYNQNRACLLPEKGLPAPGPYSTPLRTPLWNGSNHSIETQS   60
  61 SSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCH  120
 121 RDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVG  180
 181 ELIECAKRTRKPSLPSASWANTLRTTAQNNVSLWTLTSGTSSVNSPKCIIKTVEFAKQLP  240
 241 GFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTD  300
 301 LVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRR  360
 361 PSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQP  420
 421 GGGGRDGGGLPRQAAVAPASAPAPTEAARPPTPRDRPRHMDTALALRPGFSLPFYRPCDP  480
 481 APALPPPALPGSTGDLPWGTGREEAATPWTEAWALSGLPAPTAWADVRGRGQELSEAPGP  540
 541 GSQDGSWGPRVHQDTPLPSSPHLHHQQTPGLGSPILRTHKPLLPSWGTSTSPLPRLVTEG  600
 601 VGQGRGVPPVHTLPYQPQVLILAGFVFILIFLF*
Interface Residues: 91, 92, 94, 95, 101, 102, 104, 105, 108, 109, 133, 155, 157, 159, 162, 164
3D-footprint Homologues: 6fbq_A, 7wnh_D, 6l6q_B, 1lo1_A, 3g9m_B, 1a6y_A, 4oln_B, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B
Binding Motifs: RARA_full_1 ArGGTCAAAAGGTCA
RARA_full_2 arrGGTCAwsyrRGGTCA
RARA_full_3 AGGTCAasyArAGGTCA
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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