Transcription Factor

						

			
Accessions: 4iri_A (3D-footprint 20231221)

			
Names: ERG_HUMAN, Transcriptional regulator ERG, Transforming protein ERG
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P11308
Length: 94
Pfam Domains:      2-84 Ets-domain
Sequence: 
(in bold interface residues)		   1 GQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRA   60
  61 LRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPH
Interface Residues: 55, 56, 58, 59, 60, 62, 63, 77
3D-footprint Homologues: 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A
Binding Motifs: 4iri_A CGGAag
Binding Sites: 4iri_B
4iri_C
			
Publications: Regan M.C, Horanyi P.S, Pryor E.E, Sarver J.L, Cafiso D.S, Bushweller J.H. Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. Proceedings of the National Academy of Sciences of the United States of America 110:13374-9 (2013). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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