Transcription Factor

						

			
Accessions: T044267_1.02 (CISBP 1.02)

			
Names: T044267_1.02;, ZNF423
Organisms: Homo sapiens
Libraries: CISBP 1.02 1
1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed]
Uniprot: Q2M1K9
Notes: family:C2H2 ZF
Length: 1285
Pfam Domains:     66-91 C2H2-type zinc finger
  138-160 Zinc finger, C2H2 type
  138-160 C2H2-type zinc finger
  153-177 Zinc-finger double domain
  166-188 C2H2-type zinc finger
  182-204 Zinc-finger double domain
  194-216 Zinc finger, C2H2 type
  194-216 C2H2-type zinc finger
  208-233 Zinc-finger double domain
  221-257 C2H2 type zinc-finger (2 copies)
  222-244 Zinc finger, C2H2 type
  222-246 C2H2-type zinc finger
  222-244 C2H2-type zinc finger
  264-286 C2H2-type zinc finger
  265-345 C2H2 type zinc-finger (2 copies)
  323-345 C2H2-type zinc finger
  409-433 C2H2-type zinc finger
  480-503 C2H2-type zinc finger
  480-504 C2H2-type zinc finger
  517-542 C2H2-type zinc finger
  518-540 C2H2-type zinc finger
  632-655 C2H2-type zinc finger
  632-654 C2H2-type zinc finger
  663-684 C2H2-type zinc finger
  664-684 C2H2-type zinc finger
  692-710 C2H2-type zinc finger
  692-713 Zinc finger, C2H2 type
  692-715 C2H2-type zinc finger
  720-743 C2H2-type zinc finger
  781-803 C2H2-type zinc finger
  807-830 C2H2-type zinc finger
  930-952 C2H2-type zinc finger
  930-954 C2H2-type zinc finger
  944-968 Zinc-finger double domain
  961-981 C2H2-type zinc finger
1063-1079 C2H2-type zinc finger
1119-1150 C2H2 type zinc-finger (2 copies)
1120-1141 C2H2-type zinc finger
1121-1143 C2H2-type zinc finger
1198-1209 C2H2-type zinc finger
1229-1252 C2H2-type zinc finger
Sequence: 
(in bold interface residues)		   1 MHKKRVEEGEASDFSLAWDSSVTAAGGLEGEPECDQKTSRALEDRNSVTSQEERNEDDED   60
  61 MEDESIYTCDHCQQDFESLADLTDHRAHRCPGDGDDDPQLSWVASSPSSKDVASPTQMIG  120
 121 DGCDLGLGEEEGGTGLPYPCQFCDKSFIRLSYLKRHEQIHSDKLPFKCTYCSRLFKHKRS  180
 181 RDRHIKLHTGDKKYHCHECEAAFSRSDHLKIHLKTHSSSKPFKCTVCKRGFSSTSSLQSH  240
 241 MQAHKKNKEHLAKSEKEAKKDDFMCDYCEDTFSQTEELEKHVLTRHPQLSEKADLQCIHC  300
 301 PEVFVDENTLLAHIHQAHANQKHKCPMCPEQFSSVEGVYCHLDSHRQPDSSNHSVSPDPV  360
 361 LGSVASMSSATPDSSASVERGSTPDSTLKPLRGQKKMRDDGQGWTKVVYSCPYCSKRDFN  420
 421 SLAVLEIHLKTIHADKPQQSHTCQICLDSMPTLYNLNEHVRKLHKNHAYPVMQFGNISAF  480
 481 HCNYCPEMFADINSLQEHIRVSHCGPNANPSDGNNAFFCNQCSMGFLTESSLTEHIQQAH  540
 541 CSVGSAKLESPVVQPTQSFMEVYSCPYCTNSPIFGSILKLTKHIKENHKNIPLAHSKKSK  600
 601 AEQSPVSSDVEVSSPKRQRLSASANSISNGEYPCNQCDLKFSNFESFQTHLKLHLELLLR  660
 661 KQACPQCKEDFDSQESLLQHLTVHYMTTSTHYVCESCDKQFSSVDDLQKHLLDMHTFVLY  720
 721 HCTLCQEVFDSKVSIQVHLAVKHSNEKKMYRCTACNWDFRKEADLQVHVKHSHLGNPAKA  780
 781 HKCIFCGETFSTEVELQCHITTHSKKYNCKFCSKAFHAIILLEKHLREKHCVFDAATENG  840
 841 TANGVPPMATKKAEPADLQGMLLKNPEAPNSHEASEDDVDASEPMYGCDICGAAYTMEVL  900
 901 LQNHRLRDHNIRPGEDDGSRKKAEFIKGSHKCNVCSRTFFSENGLREHLQTHRGPAKHYM  960
 961 CPICGERFPSLLTLTEHKVTHSKSLDTGTCRICKMPLQSEEEFIEHCQMHPDLRNS
LTG 1020
1021 FRCVVCMQTVTSTLELKIHGTFHMQKLAGSSAASSPNGQGLQKLYKCALCLKEFRSKQDL 1080
1081 VKLDVNGLPYGLCAGCMARSANGQVGGLAPPEPADRPCAGLRCPECSVKFESAEDLESHM 1140
1141 QVDHRDLTPETSGPRKGTQTSPVPRKKTYQCIKCQMTFENEREIQIHVANHMIEEGINHE 1200
1201 CKLCNQMFDSPAKLLCHLIEHSFEGMGGTFKCPVCFTVFVQANKLQQHIFAVHGQEDKIY 1260
1261 DCSQCPQKFFFQTELQNHTMSQHAQ
Interface Residues: 138, 149, 150, 151, 152, 155, 156, 176, 177, 178, 179, 180, 181, 183, 184, 187, 204, 205, 206, 207, 208, 210, 211, 233, 234, 235, 236, 238, 239, 274, 275, 276, 277, 279, 280, 940, 941, 942, 943, 945, 946, 970, 972, 973, 1240, 1242, 1243, 1246
3D-footprint Homologues: 2kmk_A, 1mey_C, 1ubd_C, 4m9v_C, 2i13_A, 4f6m_A, 1tf6_A, 4r2q_A, 4x9j_A, 1g2d_F, 2prt_A, 2gli_A, 1g2f_F, 2wbs_A, 4is1_C, 1llm_D, 1f2i_J, 2drp_D, 1yuj_A
Binding Motifs: M3836_1.02 kCACCCwWGGGTGC
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.