Transcription Factor

						

			
Accessions: 4y5w_D (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 471
Pfam Domains:    24-117 STAT protein, all-alpha domain
  119-354 STAT protein, DNA binding domain
  365-439 SH2 domain
Sequence: 
(in bold interface residues)		   1 KFKTGLRRLQHRVGEIHLLREALQKEALAMLLQETTGELEAAKALVLKRIQIWKRQQQLA   60
  61 GNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELTRASLTGRLDEVLRTLVTSCFL  120
 121 VEKQPPQVLKTQTKFQAGVRFLLGLRFLGAPAKPPLVRADMVTEKQARETGEIINNTVPL  180
 181 ENSIPGNCCSALFKNLLLKKIKRCEGTESVTEEKCAVLFSASFTLGPIQLQALSLPLVVI  240
 241 VHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTNRGLLPEH  300
 301 FLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYW  360
 361 SDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIGSPQIENIQPFSAKDL  420
 421 SIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGGRGVPATIKMTVE
Interface Residues: 130, 205, 241, 242, 243, 244, 245
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 4y5w_BD TTCnngg
Binding Sites: 4y5w_E
4y5w_F
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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