Transcription Factor
| Accessions: | T093271_1.02 (CISBP 1.02), O43763 (JASPAR 2024) |
| Names: | T093271_1.02;, TLX2, Homeobox protein Hox-11L1, Neural crest homeobox protein, T-cell leukemia homeobox protein 2, TLX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 284 |
| Pfam Domains: | 158-214 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MEPGMLGPHNLPHHEPISFGIDQILSGPETPGGGLGLGRGGQGHGENGAFSGGYHGASGY 60 61 GPAGSLAPLPGSSGVGPGGVIRVPAHRPLPVPPPAGGAPAVPGPSGLGGAGGLAGLTFPW 120 121 MDSGRRFAKDRLTAALSPFSGTRRIGHPYQNRTPPKRKKPRTSFSRSQVLELERRFLRQK 180 181 YLASAERAALAKALRMTDAQVKTWFQNRRTKWRRQTAEEREAERHRAGRLLLHLQQDALP 240 241 RPLRPPLPPDPLCLHNSSLFALQNLQPWAEDNKVASVSGLASVV |
| Interface Residues: | 75, 80, 147, 152, 157, 158, 159, 160, 161, 199, 200, 202, 203, 206, 207, 209, 210, 211, 214, 221, 224, 225 |
| 3D-footprint Homologues: | 8gcc_A, 3a01_E, 4j19_B, 5zjt_E, 1fjl_B, 6a8r_A, 8pmf_A, 1puf_A, 1ig7_A, 3cmy_A, 5zfz_A, 3d1n_M, 8ejp_B, 1zq3_P, 2lkx_A, 6m3d_C, 1nk2_P, 2ld5_A, 7q3o_C, 6es3_K, 8osb_E, 7psx_B, 1au7_A, 5hod_A, 3lnq_A, 8eml_B, 1b72_A, 5jlw_D, 3rkq_B, 4xrs_G, 2hdd_A, 9b8u_A, 4cyc_A, 2r5y_A, 1puf_B, 8ik5_C, 1jgg_B, 5flv_I, 2hos_A, 1e3o_C, 2xsd_C, 1le8_A, 7xrc_C, 1k61_B, 1o4x_A, 4qtr_D, 1mnm_C, 1du0_A, 2a07_J |
| Binding Motifs: | M0891_1.02 wyrawtrsyy MA1577.1 yyAATTAr MA1577.2 yAATTA |
| Publications: | Shimizu H., Kang M., Iitsuka Y., Ichinose M., Tokuhisa T., Hatano M. Identification of an optimal Ncx binding sequence required for transcriptional activation. FEBS Lett. 475:170-174 (2000). [Pubmed] |
| Related annotations: | PaperBLAST |
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