Transcription Factor
| Accessions: | T093397_1.02 (CISBP 1.02), NKX2-5 (HT-SELEX2 May2017), NKX25_HUMAN (HOCOMOCO 10), P52952 (JASPAR 2024) |
| Names: | NKX2-5, T093397_1.02;, ENSG00000183072, Cardiac-specific homeobox, Homeobox protein CSX, Homeobox protein NK-2 homolog E, Homeobox protein Nkx-2.5, NKX25_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, HT-SELEX2 May2017 2, HOCOMOCO 10 3, JASPAR 2024 4 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] 3 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 4 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | family:Homeodomain, TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 324 |
| Pfam Domains: | 139-195 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MFPSPALTPTPFSVKDILNLEQQQRSLAAAGELSARLEATLAPSSCMLAAFKPEAYAGPE 60 61 AAAPGLPELRAELGRAPSPAKCASAFPAAPAFYPRAYSDPDPAKDPRAEKKELCALQKAV 120 121 ELEKTEADNAERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTST 180 181 QVKIWFQNRRYKCKRQRQDQTLELVGLPPPPPPPARRIAVPVLVRDGKPCLGDSAPYAPA 240 241 YGVGLNPYGYNAYPAYPGYGGAACSPGYSCTAAYPAGPSPAQPATAAANNNFVNFGVGDL 300 301 NAVQSPGIPQSNSGVSTLHGIRAW |
| Interface Residues: | 139, 140, 141, 142, 180, 181, 183, 184, 187, 188, 191, 192, 195 |
| 3D-footprint Homologues: | 1ig7_A, 6a8r_A, 3cmy_A, 1puf_B, 5zfz_A, 1fjl_B, 5zjt_E, 2h1k_B, 1puf_A, 3l1p_A, 1nk2_P, 1zq3_P, 6m3d_C, 2lkx_A, 7q3o_C, 6es3_K, 2ld5_A, 2hdd_A, 5jlw_D, 4cyc_A, 2r5y_A, 1jgg_B, 4xrs_G, 2hos_A, 1au7_A, 5flv_I, 3lnq_A, 3a01_E, 7psx_B, 1b72_A, 5hod_A, 3rkq_B, 7xrc_C, 1e3o_C, 4j19_B, 2xsd_C, 1le8_A, 4xrm_B, 1mnm_C, 1du0_A, 1k61_B, 1o4x_A, 8g87_X, 4qtr_D |
| Binding Motifs: | M3632_1.02 TyAAGTG NKX2-5_3 asCACTTras NKX2-5_methyl_1 mCCACTTrAs NKX2-5_methyl_2 sTCGTTgAs NKX25_HUMAN.H10MO.C|M01375 tyAAGTG MA0063.2 rmCACTCAAva MA0063.3 CACTCAA |
| Binding Sites: | MA0063.2.1 MA0063.2.10 MA0063.2.11 / MA0063.2.7 MA0063.2.12 MA0063.2.13 / MA0063.2.8 MA0063.2.14 / MA0063.2.9 MA0063.2.10 / MA0063.2.15 MA0063.2.11 / MA0063.2.16 MA0063.2.17 MA0063.2.12 / MA0063.2.18 MA0063.2.13 / MA0063.2.19 MA0063.2.2 / MA0063.2.6 / MA0063.2.9 MA0063.2.14 / MA0063.2.20 MA0063.2.3 MA0063.2.4 / MA0063.2.7 MA0063.2.5 MA0063.2.6 MA0063.2.5 / MA0063.2.8 MA0063.2.15 MA0063.2.16 MA0063.2.17 MA0063.2.18 MA0063.2.19 MA0063.2.20 MA0063.2.4 MA0063.3.1 / MA0063.3.10 / MA0063.3.11 / MA0063.3.16 / MA0063.3.19 / MA0063.3.2 / MA0063.3.3 / MA0063.3.6 / MA0063.3.9 MA0063.3.12 MA0063.3.13 MA0063.3.14 / MA0063.3.20 / MA0063.3.5 / MA0063.3.7 MA0063.3.15 MA0063.3.17 MA0063.3.18 MA0063.3.4 MA0063.3.8 |
| Publications: | Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science 351:1450-4 (2016). [Pubmed] |
| Related annotations: | PaperBLAST |
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