Transcription Factor
| Accessions: | NR1H4_MOUSE (HOCOMOCO 10), Q60641 (JASPAR 2024) |
| Names: | Bile acid receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, NR1H4_MOUSE, Nuclear receptor subfamily 1 group H member 4, Retinoid X receptor-interacting protein 14, RXR-interacting protein 14 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q60641 |
| Length: | 488 |
| Pfam Domains: | 137-203 Zinc finger, C4 type (two domains) 293-465 Ligand-binding domain of nuclear hormone receptor |
| Sequence: (in bold interface residues) | 1 MVMQFQGLENPIQISLHHSHRLSGFVPEGMSVKPAKGMLTEHAAGPLGQNLDLESYSPYN 60 61 NVPFPQVQPQISSSSYYSNLGFYPQQPEDWYSPGIYELRRMPAETGYQGETEVSEMPVTK 120 121 KPRMAAASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNC 180 181 VMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTANEDDS 240 241 EGRDLRQVTSTTKFCREKTELTADQQTLLDYIMDSYNKQRMPQEITNKILKEEFSAEENF 300 301 LILTEMATSHVQILVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPAGH 360 361 ADLLEERIRKSGISDEYITPMFSFYKSVGELKMTQEEYALLTAIVILSPDRQYIKDREAV 420 421 EKLQEPLLDVLQKLCKMYQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPL 480 481 LCEIWDVQ |
| Interface Residues: | 146, 147, 149, 150, 156, 157, 159, 160, 163, 164, 188, 222, 224, 225, 238 |
| 3D-footprint Homologues: | 6fbq_A, 7wnh_D, 6l6q_B, 3g9m_B, 1a6y_A, 1lo1_A, 4oln_B, 8hbm_B, 5krb_G, 2han_B, 1kb2_B, 2a66_A, 2nll_B, 1lat_A, 7xv6_B, 2ff0_A, 1dsz_A, 4umm_E, 3cbb_A, 8cef_H, 4iqr_B, 2han_A, 1hcq_E, 5cbz_E, 4tnt_B, 5e69_A, 4hn5_B, 5emc_A, 7prw_B, 5cbx_B, 3g6t_A, 1r4i_A |
| Binding Motifs: | NR1H4_MOUSE.H10MO.C|M01254 rrGGTCAatGaCCT MA1110.2 vsAGGTCAsk MA1110.3 AGGTCA |
| Binding Sites: | MA1110.3.15 MA1110.3.1 / MA1110.3.10 / MA1110.3.11 / MA1110.3.12 / MA1110.3.13 / MA1110.3.14 / MA1110.3.16 / MA1110.3.17 / MA1110.3.18 / MA1110.3.19 / MA1110.3.2 / MA1110.3.4 / MA1110.3.5 / MA1110.3.6 / MA1110.3.7 / MA1110.3.8 / MA1110.3.9 MA1110.2.1 MA1110.2.10 / MA1110.2.13 MA1110.2.11 / MA1110.2.14 MA1110.2.12 / MA1110.2.15 MA1110.2.13 / MA1110.2.17 MA1110.2.14 / MA1110.2.18 MA1110.2.15 / MA1110.2.19 MA1110.2.16 / MA1110.2.20 MA1110.2.17 MA1110.2.18 MA1110.2.19 MA1110.2.2 MA1110.2.20 MA1110.2.3 / MA1110.2.4 MA1110.2.4 / MA1110.2.5 MA1110.2.5 / MA1110.2.6 MA1110.2.6 / MA1110.2.7 MA1110.2.7 / MA1110.2.8 MA1110.2.8 / MA1110.2.9 MA1110.2.11 / MA1110.2.9 MA1110.2.10 MA1110.2.12 MA1110.2.16 MA1110.2.3 MA1110.3.20 MA1110.3.3 |
| Publications: | Hoeke MO, Heegsma J, Hoekstra M, Moshage H, Faber KN. Human FXR regulates SHP expression through direct binding to an LRH-1 binding site, independent of an IR-1 and LRH-1. PLoS One : (2014). [Pubmed] |
| Related annotations: | PaperBLAST |
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