Transcription Factor
| Accessions: | NKX2-8_DBD (HumanTF 1.0) |
| Names: | Homeobox protein NK-2 homolog H, Homeobox protein Nkx-2.8, NKX2-8, NKX28_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | O15522 |
| Notes: | Ensembl ID: ENSG00000136327; DNA-binding domain sequence; TF family: homeodomain; Clone source: Gene synthesis |
| Length: | 105 |
| Pfam Domains: | 28-84 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SLETSPPDSSQRPSARPASPGSDAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQL 60 61 ASLLRLTPTQVKIWFQNHRYKLKRARAPGAAESPDLAASAELHAA |
| Interface Residues: | 28, 29, 30, 31, 69, 70, 72, 73, 76, 77, 80, 81, 84, 85, 86 |
| 3D-footprint Homologues: | 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 3d1n_M, 2lkx_A, 1nk2_P, 1zq3_P, 7q3o_C, 6es3_K, 1puf_B, 2ld5_A, 3a01_E, 1jgg_B, 3rkq_B, 4xrs_G, 2hdd_A, 1au7_A, 2r5y_A, 6m3d_C, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 7psx_B, 3lnq_A, 5jlw_D, 1e3o_C, 1le8_A, 7xrc_C, 4j19_B, 2xsd_C, 1ig7_A, 1o4x_A, 1du0_A, 4qtr_D, 4cyc_A, 5hod_A |
| Binding Motifs: | NKX2-8_DBD sCACTYvav |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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