Transcription Factor
| Accessions: | UP00194A (UniPROBE 20160601) |
| Names: | Homeodomain protein IRXA3, Iroquois homeobox protein 4, Iroquois related homeobox 4 (Drosophila), Iroquois-class homeodomain protein IRX-4, Irx4 |
| Organisms: | Mus musculus |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q9QY61 |
| Description: | Iroquois related homeobox 4 (Drosophila) |
| Length: | 96 |
| Pfam Domains: | 19-76 Homeobox domain 34-73 Homeobox KN domain |
| Sequence: (in bold interface residues) | 1 PALSQYPYDRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTL 60 61 TQVSTWFANARRRLKKENKMTWPPRNKCADEKRPYG |
| Interface Residues: | 19, 20, 21, 23, 61, 62, 64, 65, 68, 69, 70, 72, 73, 75, 76 |
| 3D-footprint Homologues: | 6fqp_B, 5jlw_D, 3cmy_A, 2r5y_A, 1puf_B, 3d1n_M, 4cyc_A, 1fjl_B, 2lkx_A, 2ld5_A, 1ig7_A, 2xsd_C, 7xrc_C, 2hdd_A, 1mnm_C, 6fqq_E, 4xrm_B, 5zfz_A, 1nk2_P, 1b72_A, 7psx_B, 4xrs_G, 2d5v_B, 1k61_B, 5zjt_E, 3rkq_B, 1o4x_A, 1du0_A, 5flv_I, 3a01_E, 2h1k_B, 1le8_B, 1puf_A, 2hos_A |
| Binding Motifs: | UP00194A_1 wawrwACATGTwawwcw |
| Binding Sites: | AAAACATG AAACATGT AACATGTA AACATGTT AATTACAT ACAACATG ACATGTAA ACATGTAT ACATGTTG ATCATGTA ATGTAAAA ATGTACAA ATTACATG CATGTAAA CATGTACA CTTGTAAC CTTGTACA GTACAACA TCATGTAA TTACATAA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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