Transcription Factor
| Accessions: | UP00501A (UniPROBE 20160601), UP00501B (UniPROBE 20160601) |
| Names: | P. miniata Tbrain (T-box transcription factor), PmTbr_rep1, PmTbr_rep2 |
| Organisms: | Patiria miniata |
| Libraries: | UniPROBE 20160601 1 1 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Description: | P. miniata Tbrain (T-box transcription factor) |
| Length: | 184 |
| Pfam Domains: | 4-181 T-box |
| Sequence: (in bold interface residues) | 1 KASVFLCNSELWRKFHEHRTEMIITKQGRRMFPQLVFRLSGLNPAAHYNVFVDMVIADPN 60 61 SWKFQSGKWVATGKSDGVPRATGIYKHPDSPNTGEHWMRQDIAFSKLKLTNNRGKDSGYL 120 121 MINSMHIYQPRIHVLDLTGARVLQTHSFPETQFIGVTAYQNTDITQLKIDHNPFAKGFRD 180 181 NYDS |
| Interface Residues: | 29, 157, 158, 174, 177, 178 |
| 3D-footprint Homologues: | 4a04_B, 1h6f_B, 5flv_I, 1xbr_B, 6f59_B, 2x6v_A |
| Binding Motifs: | UP00501A_1 / UP00501A_2 yskctrrAGGTGTGAAywwamst UP00501A_3 / UP00501A_4 mrwmhsCsAGGTGACAtawstsv UP00501B_1 / UP00501B_2 smsrsmrAGGTGYGAAmtwrdw UP00501B_3 / UP00501B_4 whyccgkAGGTGwygsymshcs |
| Binding Sites: | AAGTGTGA AGGTGCGA AGGTGTCA AGGTGTCG AGGTGTGA AGGTGTTA AGTGTGAA ATCACACC GGGTGTGA GGTGCGAA GGTGTGAA GTGTGAAA GTGTGAAC AACACCTC AAGGTGTC ACACCTCC ACACCTCG AGGTGCTA AGGTGTTG CACACCTC CTCACACC GACACCTA GACACCTC |
| Publications: | Cheatle Jarvela AM, Brubaker L, Vedenko A, Gupta A, Armitage BA, Bulyk ML, Hinman VF. Modular evolution of DNA-binding preference of a Tbrain transcription factor provides a mechanism for modifying gene regulatory networks. Mol Biol Evol 31:2672-88 (2014). [Pubmed] |
| Related annotations: | PaperBLAST |
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