Transcription Factor
| Accessions: | Elk3_DBD (HumanTF 1.0), UP00420A (UniPROBE 20160601) |
| Names: | Elk3, ELK3_MOUSE, ETS domain-containing protein Elk-3, ETS-related protein ERP, ETS-related protein NET, D430049E23Rik, Erp, Etrp, member of ETS oncogene family, Sap-2 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | Q62346 |
| Description: | ELK3, member of ETS oncogene family: ETS domain-containing protein Elk-3 |
| Notes: | Ensembl ID: ENSMUSG00000008398; DNA-binding domain sequence; TF family: ETS; Clone source: Hughes lab. |
| Length: | 103 |
| Pfam Domains: | 4-85 Ets-domain |
| Sequence: (in bold interface residues) | 1 ESAITLWQFLLHLLLDQKHEHLICWTSNDGEFKLLKAEEVAKLWGLRKNKTNMNYDKLSR 60 61 ALRYYYDKNIIKKVIGQKFVYKFVSFPDILKMDPHAVEISRES |
| Interface Residues: | 22, 56, 57, 59, 60, 61, 63, 64, 78 |
| 3D-footprint Homologues: | 2ivk_C, 2stt_A, 1dux_F, 4uno_A, 3jtg_A, 7jsa_J, 3zp5_A, 8ee9_F, 4mhg_A, 4iri_A, 4l18_B, 1yo5_C, 1awc_A, 4lg0_B, 4bqa_A, 1bc8_C |
| Binding Motifs: | UP00420A_1 ackyACCGGAAGydmms Elk3_DBD ACCGGAAGTr |
| Binding Sites: | AACCGGAA AACTTCCG ACCGGAAA ACCGGAAC ACTTCCGC ACTTCCGG AGCGGAAG AGTTCCGG ATTTCCGG CACCGGAA CACTTCCG CCCGGAAG CCGGAAAC CCGGAAGC CCGGAAGG CTTCCGGA CTTCCGGC GACCGGAA TACCGGAA TTCCGGAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Wei G-H, Badis G, Berger MF, Kivioja T, Palin K, Enge M, Bonke M, Jolma A, Varjosalo M, Gehrke AR, Yan J, Talukder S, Turunen M, Taipale M, Stunnenberg HG, Ukkonen E, Hughes TR, Bulyk ML, Taipale J. Genome-wide analysis of ETS family DNA-binding in vitro and in vivo. The EMBO Journal. Epub 2010 Jun 1. doi:10.1038/emboj.2010.106 [Pubmed] |
| Related annotations: | PaperBLAST |
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