Transcription Factor
| Accessions: | HES5_DBD (HumanTF 1.0), HES5 (HT-SELEX2 May2017) |
| Names: | bHLHb38, Class B basic helix-loop-helix protein 38, Hairy and enhancer of split 5, HES5, HES5_HUMAN, Transcription factor HES-5, ENSG00000197921 |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HT-SELEX2 May2017 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Uniprot: | Q5TA89 |
| Notes: | Ensembl ID: ENSG00000197921; DNA-binding domain sequence; TF family: bHLH; Clone source: Gene synthesis, TF family: bHLH experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: bHLH experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 113 |
| Pfam Domains: | 16-69 Helix-loop-helix DNA-binding domain 84-109 Hairy Orange |
| Sequence: (in bold interface residues) | 1 PSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKADIL 60 61 EMAVSYLKHSKAFVAAAGPKSLHQDYSEGYSWCLQEAVQFLTLHAASDTQMKL |
| Interface Residues: | 17, 18, 19, 20, 22, 23, 26, 27, 56 |
| 3D-footprint Homologues: | 7f2f_B, 1an4_A, 4h10_B, 8osl_O, 4h10_A, 5gnj_I, 7ssa_L, 8osl_P, 5nj8_C, 7xhv_B, 5v0l_B, 7xi3_B |
| Binding Motifs: | HES5_DBD yGrCACGTGCCr HES5_3 GGCACGTGyc HES5_methyl_1 GgCACGTGyc HES5_methyl_2 vCACaCky |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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