Transcription Factor
| Accessions: | T005325_1.02 (CISBP 1.02), UP00351A (UniPROBE 20160601), P36093 (JASPAR 2024) |
| Names: | PHD1, T005325_1.02;, Putative transcription factor PHD1, YKL043W, YKL256, PHD1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Transcriptional activator that enhances pseudohyphal growth; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA, an A. nidulans developmental re.. |
| Notes: | experiment type:PBM, family:APSES |
| Length: | 366 |
| Pfam Domains: | 208-268 KilA-N domain |
| Sequence: (in bold interface residues) | 1 MYHVPEMRLHYPLVNTQSNAAITPTRSYDNTLPSFNELSHQSTINLPFVQRETPNAYANV 60 61 AQLATSPTQAKSGYYCRYYAVPFPTYPQQPQSPYQQAVLPYATIPNSNFQPSSFPVMAVM 120 121 PPEVQFDGSFLNTLHPHTELPPIIQNTNDTSVARPNNLKSIAAASPTVTATTRTPGVSST 180 181 SVLKPRVITTMWEDENTICYQVEANGISVVRRADNNMINGTKLLNVTKMTRGRRDGILRS 240 241 EKVREVVKIGSMHLKGVWIPFERAYILAQREQILDHLYPLFVKDIESIVDARKPSNKASL 300 301 TPKSSPAPIKQEPSDNKHEIATEIKPKSIDALSNGASTQGAGELPHLKINHIDTEAQTSR 360 361 AKNELS |
| Interface Residues: | 231, 232, 248, 251, 255 |
| 3D-footprint Homologues: | 4ux5_A |
| Binding Motifs: | UP00351A_1 rrkkavCaTGCATmamgrwrg M0096_1.02 GmTGCAkG MA0355.1 msmTGCAkcm MA0355.2 smTGCA |
| Binding Sites: | ACCTGCAT AGATGCAT ATGCAGCA ATGCATAA ATGCATGC CATGCAGG CATGCATA CATGCATC CATGCATG CCTGCAGC CCTGCAGG CCTGCATC CGCTGCAG CTGATGCA CTGCATCA GATGCATC GTGCTGCA TGCATGCA ATGCATAC GCTGCAGC |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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