Transcription Factor
| Accessions: | ATF2_HUMAN (HOCOMOCO 10), P15336 (JASPAR 2024) |
| Names: | Activating transcription factor 2, ATF2_HUMAN, cAMP response element-binding protein CRE-BP1, cAMP-dependent transcription factor ATF-2, cAMP-responsive element-binding protein 2, CREB-2, Cyclic AMP-dependent transcription factor ATF-2, Cyclic AMP-responsive element-binding protein 2, EC 2.3.1.48, HB16, Histone acetyltransferase ATF2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P15336 |
| Length: | 505 |
| Pfam Domains: | 351-404 Basic region leucine zipper 352-411 bZIP transcription factor |
| Sequence: (in bold interface residues) | 1 MKFKLHVNSARQYKDLWNMSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARN 60 61 DSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIR 120 121 SKIEEPSVVETTHQDSPLPHPESTTSDEKEVPLAQTAQPTSAIVRPASLQVPNVLLTSSD 180 181 SSVIIQQAVPSPTSSTVITQAPSSNRPIVPVPGPFPLLLHLPNGQTMPVAIPASITSSNV 240 241 HVPAAVPLVRPVTMVPSVPGIPGPSSPQPVQSEAKMRLKAALTQQHPPVTNGDTVKGHGS 300 301 GLVRTQSEESRPQSLQQPATSTTETPASPAHTTPQTQSTSGRRRRAANEDPDEKRRKFLE 360 361 RNRAAASRCRQKRKVWVQSLEKKAEDLSSLNGQLQSEVTLLRNEVAQLKQLLLAHKDCPV 420 421 TAMQKKSGYHTADKDDSSEDISVPSSPHTEAIQHSSVSTSNGVSSTSKAEAVATSVLTQM 480 481 ADQSTEPALSQIVMAPSSQSQPSGS |
| Interface Residues: | 8, 10, 11, 14, 15, 17, 18, 38, 39, 40, 41, 43, 44, 46, 47, 48, 356, 357, 358, 362, 363, 365, 366, 369, 370 |
| 3D-footprint Homologues: | 1ubd_C, 5ei9_F, 7eyi_G, 1mey_C, 7y3m_I, 6blw_A, 2i13_A, 7n5w_A, 8cuc_F, 6jnm_A, 5kl3_A, 5yj3_D, 8h9h_G, 6wmi_A, 2wbs_A, 7y3l_A, 6a57_A, 4x9j_A, 2gli_A, 1tf3_A, 2jpa_A, 2wt7_B, 4eot_A, 7x5e_E, 2wt7_A, 5vpe_C, 5vpe_D, 5t01_B, 1dh3_C |
| Binding Motifs: | ATF2_HUMAN.H10MO.B|M01019 rTGACGTmA MA1632.1 wrATGAbGTCAty MA1632.2 ATGAbGTCAt |
| Binding Sites: | MA1632.2.1 MA1632.2.2 / MA1632.2.3 MA1632.2.15 MA1632.1.1 MA1632.1.2 MA1632.1.3 MA1632.1.4 MA1632.1.1 / MA1632.1.5 MA1632.1.10 / MA1632.1.6 MA1632.1.11 MA1632.1.12 MA1632.1.13 MA1632.1.14 MA1632.1.15 MA1632.1.16 / MA1632.1.7 MA1632.1.17 MA1632.1.18 MA1632.1.19 MA1632.1.20 MA1632.1.2 / MA1632.1.6 MA1632.1.3 / MA1632.1.7 MA1632.1.4 / MA1632.1.8 MA1632.1.5 / MA1632.1.9 MA1632.1.10 MA1632.1.11 MA1632.1.12 MA1632.1.13 MA1632.1.14 MA1632.1.15 MA1632.1.16 MA1632.1.17 MA1632.1.18 MA1632.1.19 MA1632.1.20 MA1632.1.8 MA1632.1.9 MA1632.2.4 MA1632.2.5 MA1632.2.11 MA1632.2.10 MA1632.2.12 MA1632.2.13 MA1632.2.14 MA1632.2.16 MA1632.2.17 / MA1632.2.20 MA1632.2.18 MA1632.2.19 MA1632.2.6 MA1632.2.7 MA1632.2.8 MA1632.2.9 |
| Publications: | Lee S. H., Bahn J. H., Whitlock N. C., Baek S. J. Activating transcription factor 2 (ATF2) controls tolfenamic acid-induced ATF3 expression via MAP kinase pathways.. Oncogene 29:5182-5192 (2010). [Pubmed] |
| Related annotations: | PaperBLAST |
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