Transcription Factor

Accessions: STA5A_MOUSE (HOCOMOCO 10), P42230 (JASPAR 2024)
Names: Mammary gland factor, Signal transducer and activator of transcription 5A, STA5A_MOUSE
Organisms: Mus musculus
Libraries: HOCOMOCO 10 1, JASPAR 2024 2
1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Length: 793
Pfam Domains: 2-125 STAT protein, protein interaction domain
138-330 STAT protein, all-alpha domain
332-583 STAT protein, DNA binding domain
595-669 SH2 domain
Sequence:
(in bold interface residues)
1 MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRGQATQL 60
61 LEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLV 120
121 REANNCSSPAGVLVDAMSQKHLQINQRFEELRLITQDTENELKKLQQTQEYFIIQYQESL 180
181 RIQAQFAQLGQLNPQERMSRETALQQKQVSLETWLQREAQTLQQYRVELAEKHQKTLQLL 240
241 RKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLC 300
301 QQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKL 360
361 NVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMS 420
421 LKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATA 480
481 TVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNI 540
541 SSNHLEDYNSMSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNK 600
601 QQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPDRNLWNLKPFTTRDFSIRSLADRL 660
661 GDLNYLIYVFPDRPKDEVFAKYYTPVLAKAVDGYVKPQIKQVVPEFVNASTDAGASATYM 720
721 DQAPSPVVCPQPHYNMYPPNPDPVLDQDGEFDLDESMDVARHVEELLRRPMDSLDARLSP 780
781 PAGLFTSARSSLS
Interface Residues: 343, 430, 433, 470, 471, 472, 473, 474
3D-footprint Homologues: 1bf5_A, 4y5w_B, 1bg1_A
Binding Motifs: STA5A_MOUSE.H10MO.A|M01363 wtTTCykrGAAaw
MA1624.1 wTTCCAAGAAah
MA1624.2 TTCCAAGAA
Binding Sites: MA1624.2.11 / MA1624.2.13 / MA1624.2.14 / MA1624.2.5
MA1624.2.10 / MA1624.2.17 / MA1624.2.18 / MA1624.2.20 / MA1624.2.9
MA1624.1.1
MA1624.1.10
MA1624.1.11 / MA1624.1.9
MA1624.1.12
MA1624.1.10 / MA1624.1.13
MA1624.1.14
MA1624.1.15
MA1624.1.16
MA1624.1.17
MA1624.1.18
MA1624.1.19
MA1624.1.2
MA1624.1.11 / MA1624.1.20
MA1624.1.3
MA1624.1.4 / MA1624.1.5
MA1624.1.5
MA1624.1.6
MA1624.1.7
MA1624.1.8
MA1624.1.8 / MA1624.1.9
MA1624.1.12
MA1624.1.13
MA1624.1.14
MA1624.1.15
MA1624.1.16
MA1624.1.17
MA1624.1.18
MA1624.1.19
MA1624.1.20
MA1624.1.3
MA1624.1.4
MA1624.1.7
MA1624.2.1
MA1624.2.12
MA1624.2.15 / MA1624.2.6
MA1624.2.16
MA1624.2.19 / MA1624.2.2
MA1624.2.3
MA1624.2.4
MA1624.2.7
MA1624.2.8
Publications: Soldaini E., John S., Moro S., Bollenbacher J., Schindler U., Leonard W. J. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.. Mol. Cell. Biol. 20:389-401 (2000). [Pubmed]
Related annotations: PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.