footprintDB - a database of transcription factors with annotated cis elements (DNA motifs and sites) and binding interfaces

Transcription Factor

Accessions:	Q15928 (JASPAR 2024)
Names:	ZN141_HUMAN
Organisms:	Homo sapiens
Libraries:	JASPAR 2024 ¹ ¹ Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Uniprot:	Q15928
Length:	474
Pfam Domains:	4-44 KRAB box 174-190 C2H2-type zinc finger 185-209 Zinc-finger double domain 198-219 C2H2-type zinc finger 215-238 Zinc-finger double domain 226-246 C2H2-type zinc finger 227-249 Zinc finger, C2H2 type 227-249 C2H2-type zinc finger 242-265 Zinc-finger double domain 254-275 C2H2-type zinc finger 255-277 Zinc finger, C2H2 type 255-277 C2H2-type zinc finger 270-294 Zinc-finger double domain 284-303 C2H2-type zinc finger 284-305 Zinc finger, C2H2 type 285-305 C2H2-type zinc finger 297-321 Zinc-finger double domain 310-331 C2H2-type zinc finger 311-333 C2H2-type zinc finger 311-333 Zinc finger, C2H2 type 326-349 Zinc-finger double domain 338-361 C2H2-type zinc finger 339-361 C2H2-type zinc finger 339-361 Zinc finger, C2H2 type 354-377 Zinc-finger double domain 366-387 C2H2-type zinc finger 367-389 Zinc finger, C2H2 type 382-405 Zinc-finger double domain 394-409 C2H2-type zinc finger 395-417 Zinc finger, C2H2 type 395-417 C2H2-type zinc finger 411-434 Zinc-finger double domain 422-443 C2H2-type zinc finger 423-445 Zinc finger, C2H2 type 423-445 C2H2-type zinc finger 438-462 Zinc-finger double domain 450-471 C2H2-type zinc finger 451-473 Zinc finger, C2H2 type 451-473 C2H2-type zinc finger
Sequence: (in bold interface residues)	1 MELLTFRDVAIEFSPEEWKCLDPDQQNLYRDVMLENYRNLVSLGVAISNPDLVTCLEQRK 60 61 EPYNVKIHKIVARPPAMCSHFTQDHWPVQGIEDSFHKLILRRYEKCGHDNLQLRKGCKSL 120 121 NECKLQKGGYNEFNECLSTTQSKILQCKASVKVVSKFSNSNKRKTRHTGEKHFKECGKSF 180 181 QKFSHLTQHKVIHAGEKPYTCEECGKAFKWSLIFNEHKRIHTGEKPFTCEECGSIFTTSS 240 241 HFAKHKIIHTGEKPYKCEECGKAFNRFTTLTKHKRIHAGEKPITCEECRKIFTSSSNFAK 300 301 HKRIHTGEKPYKCEECGKAFNRSTTLTKHKRIHTGEKPYTCEECGKAFRQSSKLNEHKKV 360 361 HTGERPYKCDECGKAFGRSRVLNEHKKIHTGEKPYKCEECGKAFRRSTDRSQHKKIHSAD 420 421 KPYKCKECDKAFKQFSLLSQHKKIHTVDKPYKCKDCDKAFKRFSHLNKHKKIHT
Interface Residues:	181, 182, 184, 185, 188, 209, 210, 212, 213, 215, 216, 238, 239, 240, 241, 243, 244, 246, 248, 266, 267, 268, 269, 272, 293, 294, 295, 296, 297, 299, 300, 302, 303, 304, 306, 311, 321, 322, 323, 324, 325, 328, 329, 349, 350, 351, 352, 353, 354, 355, 356, 357, 358, 378, 379, 380, 381, 382, 383, 384, 390, 404, 405, 406, 407, 408, 409, 412, 416, 433, 434, 435, 436, 437, 439, 440, 461, 462, 464
3D-footprint Homologues:	6jnm_A, 7w1m_H, 2lt7_A, 1tf6_A, 6a57_A, 1tf3_A, 8gn3_A, 5ei9_F, 6wmi_A, 5yj3_D, 8ssq_A, 8ssu_A, 5v3j_F, 2i13_A, 6e94_A, 5yel_A, 7n5w_A, 6u9q_A, 2drp_D, 6ml4_A, 6blw_A, 5kkq_D, 8h9h_G, 7eyi_G, 7ysf_A, 2jpa_A, 2kmk_A, 8cuc_F, 7y3l_A, 1mey_C, 5kl3_A, 1f2i_J, 5und_A, 1g2f_F, 4x9j_A, 1llm_D, 2wbs_A, 4m9v_C, 7y3m_I, 1ubd_C, 3uk3_C, 7txc_E, 5k5i_A, 2gli_A, 5k5l_F
Binding Motifs:	UN0163.1 gGGGGaCGCCCcc UN0315.1 GrGCGTCCCCcc UN0163.2 gGGGGaCGCCC
Binding Sites:	UN0163.1.1 UN0163.1.10 / UN0163.1.7 UN0163.1.11 UN0163.1.12 / UN0163.1.8 UN0163.1.13 UN0163.1.14 UN0163.1.15 / UN0163.1.9 UN0163.1.16 UN0163.1.17 UN0163.1.10 / UN0163.1.18 UN0163.1.19 UN0163.1.1 / UN0163.1.2 UN0163.1.11 / UN0163.1.17 / UN0163.1.20 UN0163.1.2 / UN0163.1.3 UN0163.1.3 / UN0163.1.4 UN0163.1.5 UN0163.1.6 UN0163.1.4 / UN0163.1.7 UN0163.1.5 / UN0163.1.8 UN0163.1.6 / UN0163.1.9 UN0315.1.1 UN0315.1.10 UN0315.1.11 UN0315.1.12 UN0315.1.13 UN0315.1.14 UN0315.1.15 UN0315.1.16 UN0315.1.17 UN0315.1.18 UN0315.1.19 / UN0315.1.9 UN0315.1.2 UN0315.1.20 UN0315.1.3 UN0315.1.4 UN0315.1.5 UN0315.1.6 UN0315.1.7 UN0315.1.8 UN0163.1.12 UN0163.1.13 UN0163.1.14 UN0163.1.15 UN0163.1.16 UN0163.1.18 UN0163.1.19 UN0163.1.20 UN0163.2.1 UN0163.2.10 / UN0163.2.12 / UN0163.2.15 / UN0163.2.17 / UN0163.2.3 UN0163.2.11 / UN0163.2.14 / UN0163.2.19 UN0163.2.13 / UN0163.2.16 / UN0163.2.18 / UN0163.2.2 / UN0163.2.5 / UN0163.2.9 UN0163.2.20 UN0163.2.4 UN0163.2.6 UN0163.2.7 UN0163.2.8
Related annotations:	PaperBLAST

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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.

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