Transcription Factor
| Accessions: | T061542_1.02 (CISBP 1.02), UP00348A (UniPROBE 20160601), P39956 (JASPAR 2024) |
| Names: | RPH1, T061542_1.02;, DNA damage-responsive transcriptional repressor RPH1, YER169W, RPH1_YEAST |
| Organisms: | Saccharomyces cerevisiae |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Description: | Transcriptional repressor of PHR1, which is a photolyase induced by DNA damage; binds to AG(4) (C(4)T) sequence upstream of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC... |
| Notes: | experiment type:PBM, family:C2H2 ZF |
| Length: | 796 |
| Pfam Domains: | 15-48 jmjN domain 222-338 JmjC domain, hydroxylase 709-732 C2H2-type zinc finger 723-749 Zinc-finger double domain 738-759 C2H2-type zinc finger 738-759 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 MTKLIAPSEIVGGVPVFKPTYEQFEDFYAYCKAINKYGMKSGVVKVIPPKEWKDKLDLPY 60 61 SAETLQKIKIKSPIQQHISGNKGLFMVQNVEKNKTYNIIQWKDLSKDYVPPEDPKARRNS 120 121 RKGSVSKSTKLKLKNFESSFNIDDFEQFRTEYTIDLSDFQNTERLKFLEEYYWKTLNFTT 180 181 PMYGADTPGSIFPEGLNVWNVAKLPNILDHMETKVPGVNDSYLYAGLWKASFSWHLEDQD 240 241 LYSINYIHFGAPKQWYSIPQEDRFKFYKFMQEQFPEEAKNCPEFLRHKMFLASPKLLQEN 300 301 GIRCNEIVHHEGEFMITYPYGYHAGFNYGYNLAESVNFALEEWLPIGKKAGKCHCISDSV 360 361 EIDVKKLAKSWRDNNKESKGTPPLNQLPNPAMPLLHRPTLKEMESSSLRSTSPDVGHFSN 420 421 FKSKSSGVSSPLLSRMKDYSNIVEPTLEDPTLKLKRISSFQEQPLNKLLKRETSQTAMLT 480 481 DHEDNIVAMSLTSMANSAASSPRLPLSRLNSSNELSNAQPLLDMTNNTLAFPRPNGPSGL 540 541 NPLLYISNKNISGISHSAPHSPVNPNISLIKRVKSPNIVTLNISRESSRSPIALNYEARQ 600 601 QHSQQHSFSTPSTVSNLSTSVLGPLSDTNDIKTPHPERPNHKTANRILKKESPVETSKSN 660 661 LILSKVASTRQEDSFTSRNDDLDKEQGSSPLNSKFAPEEIVLSGKNKIYICKECQRKFSS 720 721 GHHLTRHKKSVHSGEKPHSCPKCGKRFKRRDHVLQHLNKKIPCISNETTVDAPIMNPTVQ 780 781 PQDGKAAINQQSTPLN |
| Interface Residues: | 686, 692, 693, 694, 695, 697, 704, 705, 706, 707, 718, 719, 720, 721, 722, 723, 724, 725, 726, 727, 730, 747, 748, 749, 750, 751, 752, 753, 754, 755, 756, 759, 791, 793, 794 |
| 3D-footprint Homologues: | 2jpa_A, 2kmk_A, 5v3j_F, 7w1m_H, 1g2f_F, 8cuc_F, 7y3l_A, 3uk3_C, 7n5w_A, 6u9q_A, 7txc_E, 6blw_A, 5kkq_D, 2lt7_A, 6wmi_A, 5yel_A, 4x9j_A, 8ssq_A, 1llm_D, 5kl3_A, 2wbs_A, 1ubd_C, 5ei9_F, 1mey_C, 6ml4_A, 5und_A, 2drp_D, 8gn3_A, 1f2i_J, 5k5i_A, 4m9v_C, 2gli_A, 8h9h_G, 1tf6_A, 7ysf_A, 2i13_A, 6e94_A, 7eyi_G, 1tf3_A, 7y3m_I, 6a57_A, 5yj3_D |
| Binding Motifs: | UP00348A_1 aadrarawTTAGGGGkrgrmk M0515_1.02 wTTAGGGGtrc MA0372.1 aCCCCTwA MA0372.2 CCCCTwA |
| Binding Sites: | AAAGGGGG AAGGGGGG AATTAAGG AATTAGGG ACCCCTAA ACCCCTAT AGGGGGAA ATAGGGGG ATTAAGGG ATTAGGGG CCCCCTAA CCCCTAAA CCCCTAAC CCCCTATA CCCCTGAA CCCCTTAA CCCTTAAA TAGGGGGA TCCCTTAA AGGGGGCA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Badis G, Chan E.T, van Bakel H, Pena-Castillo L, Tillo D, Tsui K, Carlson C.D, Gossett A.J, Hasinoff M.J, Warren C.L, Gebbia M, Talukder S, Yang A, Mnaimneh S, Terterov D, Coburn D, Li Yeo A, Yeo Z.X, Clarke N.D, Lieb J.D, Ansari A.Z, Nislow C, Hughes T.R. A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. Molecular cell 32:878-87 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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