Transcription Factor
| Accessions: | P17022 (JASPAR 2024) |
| Names: | Heart development-specific gene 1 protein, Zinc finger protein 18, Zinc finger protein 535, Zinc finger protein KOX11, Zinc finger protein with KRAB and SCAN domains 6, ZNF18_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P17022 |
| Length: | 549 |
| Pfam Domains: | 36-128 SCAN domain 222-249 KRAB box 409-430 Zinc finger, C2H2 type 409-423 C2H2-type zinc finger 410-430 C2H2-type zinc finger 426-446 Zinc-finger double domain 436-458 C2H2-type zinc finger 436-458 Zinc finger, C2H2 type 436-458 C2H2-type zinc finger 451-474 Zinc-finger double domain 465-486 Zinc finger, C2H2 type 465-482 C2H2-type zinc finger 465-486 C2H2-type zinc finger 479-501 Zinc-finger double domain 491-514 C2H2-type zinc finger 492-514 Zinc finger, C2H2 type 492-514 C2H2-type zinc finger 506-530 Zinc-finger double domain 519-542 C2H2-type zinc finger 520-542 Zinc finger, C2H2 type 520-542 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MPVDLGQALGLLPSLAKAEDSQFSESDAALQEELSSPETARQLFRQFRYQVMSGPHETLK 60 61 QLRKLCFQWLQPEVHTKEQILEILMLEQFLTILPGEIQMWVRKQCPGSGEEAVTLVESLK 120 121 GDPQRLWQWISIQVLGQDILSEKMESPSCQVGEVEPHLEVVPQELGLENSSSGPGELLSH 180 181 IVKEESDTEAELALAASQPARLEERLIRDQDLGASLLPAAPQEQWRQLDSTQKEQYWDLM 240 241 LETYGKMVSGAGISHPKSDLTNSIEFGEELAGIYLHVNEKIPRPTCIGDRQENDKENLNL 300 301 ENHRDQELLHASCQASGEVPSQASLRGFFTEDEPGCFGEGENLPEALQNIQDEGTGEQLS 360 361 PQERISEKQLGQHLPNPHSGEMSTMWLEEKRETSQKGQPRAPMAQKLPTCRECGKTFYRN 420 421 SQLIFHQRTHTGETYFQCTICKKAFLRSSDFVKHQRTHTGEKPCKCDYCGKGFSDFSGLR 480 481 HHEKIHTGEKPYKCPICEKSFIQRSNFNRHQRVHTGEKPYKCSHCGKSFSWSSSLDKHQR 540 541 SHLGKKPFQ |
| Interface Residues: | 418, 419, 421, 422, 424, 425, 427, 428, 431, 436, 447, 448, 449, 450, 453, 474, 475, 476, 477, 478, 480, 481, 482, 484, 502, 503, 504, 505, 506, 507, 508, 509, 510, 513, 530, 531, 532, 533, 534, 535, 536, 537 |
| 3D-footprint Homologues: | 5v3j_F, 1tf6_A, 4x9j_A, 5kkq_D, 6wmi_A, 2i13_A, 5yel_A, 2jpa_A, 1ubd_C, 2kmk_A, 5und_A, 8ssu_A, 6ml4_A, 1llm_D, 5ei9_F, 5kl3_A, 5yj3_D, 5k5i_A, 8ssq_A, 7w1m_H, 7eyi_G, 6e94_A, 7ysf_A, 6jnm_A, 8cuc_F, 7y3l_A, 7n5w_A, 3uk3_C, 1tf3_A, 2gli_A, 1g2f_F, 8gn3_A, 6blw_A, 6u9q_A, 1mey_C, 2drp_D, 4m9v_C, 8h9h_G, 2lt7_A, 7y3m_I, 6a57_A, 5k5l_F, 2wbs_A, 7txc_E, 1f2i_J |
| Binding Motifs: | UN0317.1 swGGTGTGAAywk UN0317.2 GGTGTGAAy |
| Binding Sites: | UN0317.2.15 UN0317.1.1 UN0317.1.10 UN0317.1.11 / UN0317.1.7 UN0317.1.12 / UN0317.1.8 UN0317.1.13 UN0317.1.14 / UN0317.1.9 UN0317.1.15 UN0317.1.10 / UN0317.1.16 UN0317.1.17 / UN0317.1.19 UN0317.1.18 UN0317.1.2 / UN0317.1.3 UN0317.1.20 UN0317.1.4 UN0317.1.5 UN0317.1.4 / UN0317.1.6 UN0317.1.5 / UN0317.1.7 UN0317.1.8 UN0317.1.6 / UN0317.1.9 UN0317.1.11 UN0317.1.12 UN0317.1.13 UN0317.1.14 UN0317.1.15 UN0317.1.16 UN0317.1.17 UN0317.1.18 UN0317.1.19 UN0317.1.20 UN0317.2.1 UN0317.2.10 UN0317.2.11 UN0317.2.12 / UN0317.2.7 UN0317.2.13 UN0317.2.14 / UN0317.2.6 UN0317.2.16 UN0317.2.17 / UN0317.2.2 / UN0317.2.3 UN0317.2.18 UN0317.2.19 UN0317.2.20 UN0317.2.4 UN0317.2.5 UN0317.2.8 UN0317.2.9 |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.