Transcription Factor
| Accessions: | ZIC4 (HT-SELEX2 May2017) |
| Names: | ENSG00000174963, ZIC4 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Znf_C2H2 experiment: HT-SELEX Hamming distance: 2 cycle: 4, TF family: Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 2 cycle: 4 |
| Length: | 194 |
| Pfam Domains: | 28-47 C2H2-type zinc finger 62-83 Zinc finger, C2H2 type 63-83 C2H2-type zinc finger 76-101 Zinc-finger double domain 89-113 C2H2-type zinc finger 89-113 Zinc finger, C2H2 type 105-132 Zinc-finger double domain 119-143 C2H2-type zinc finger 149-173 C2H2-type zinc finger 149-173 Zinc finger, C2H2 type |
| Sequence: (in bold interface residues) | 1 FFRYMRQPIKQELICKWLAADGTATPSLCSKTFSTMHELVTHVTVEHVGGPEQANHICFW 60 61 EECPRQGKPFKAKYKLVNHIRVHTGEKPFPCPFPGCGKVFARSENLKIHKRTHTGEKPFR 120 121 CEFEGCERRFANSSDRKKHSHVHTSDKPYTCKVRGCDKCYTHPSSLRKHMKVHGRSPPPS 180 181 SGYDSATPSALVSP |
| Interface Residues: | 34, 35, 37, 38, 41, 71, 72, 73, 74, 75, 77, 78, 80, 81, 82, 84, 101, 102, 103, 104, 105, 107, 108, 131, 132, 133, 134, 135, 136, 137, 138, 139, 142, 161, 162, 163, 164, 165, 166, 167, 168, 169 |
| 3D-footprint Homologues: | 5v3j_F, 1ubd_C, 7w1m_H, 8cuc_F, 7y3l_A, 1tf3_A, 7n5w_A, 8ssq_A, 2kmk_A, 8ssu_A, 5kkq_D, 8gn3_A, 4x9j_A, 2gli_A, 1tf6_A, 5ei9_F, 1g2f_F, 6ml4_A, 8h9h_G, 5k5i_A, 6e94_A, 7ysf_A, 2lt7_A, 2jpa_A, 3uk3_C, 6jnm_A, 6blw_A, 1llm_D, 6u9q_A, 5yel_A, 2drp_D, 1f2i_J, 5kl3_A, 7txc_E, 7y3m_I, 6a57_A, 5yj3_D, 2wbs_A, 4m9v_C |
| Binding Motifs: | ZIC4_2 yvCcmCCyryyGygc ZIC4_methyl_1 krCCmCCyrCtGTGm |
| Related annotations: | PaperBLAST |
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