Transcription Factor

						

			
Accessions: 5d39_D (3D-footprint 20231221)

			
Names: IL-4 Stat, Signal transducer and activator of transcription 6, STAT6_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P42226
Length: 486
Pfam Domains:    26-123 STAT protein, all-alpha domain
  125-363 STAT protein, DNA binding domain
  374-452 SH2 domain
Sequence: 
(in bold interface residues)		   1 QEELKFKTGLRRLQHRVGEIHLLREALQEALAMLLQETTGELEAAKALVLKRIQIWKRQQ   60
  61 QLAGNGAPFEESLAPLQERCESLVDIYSQLQQEVGAAGGELEPKTRASLTGRLDEVLRTL  120
 121 VTSCFLVEKQPPQVLKTQTKFQAGVRFLLGLRFPAKPPLVRADMVTEKQARELESTGEII  180
 181 NNTVPLENSIPGNCCSALFKNLLLKKIKRCETESVTEEKCAVLFSASFTLGPGKLPIQLQ  240
 241 ALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVG  300
 301 TNRGLLPEHFLFLAQKIFNDNSLSMEAFQHRSVSWSQFNKEILLGRGFTFWQWFDGVLDL  360
 361 TKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSP  420
 421 QIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGVPAT  480
 481 IKMTVE
Interface Residues: 136, 250, 251, 252, 253, 254
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 5d39_BD TtcCtGgaa
5d39_D TtcC
Binding Sites: 5d39_E
5d39_F
			
Publications: Li J, Rodriguez JP, Niu F, Pu M, Wang J, Hung LW, Shao Q, Zhu Y, Ding W, Liu Y, Da Y, Yao Z, Yang J, Zhao Y, Wei GH, Cheng G, Liu ZJ, Ouyang S. Structural basis for DNA recognition by STAT6. Proc Natl Acad Sci U S A 113:13015-13020 (2016). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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