Transcription Factor

						

			
Accessions: 6u82_D (3D-footprint 20231221)

			
Names: Double homeobox protein 10, Double homeobox protein 4, DUX4_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q9UBX2
Length: 134
Pfam Domains:      4-58 Homeobox domain
    25-57 Homeobox KN domain
   79-133 Homeobox domain
  102-132 Homeobox KN domain
Sequence: 
(in bold interface residues)		   1 GRGRRRRLVWTPSQSEALRACFERNPYPGIATRERLAQAIGIPEPRVQIWFQNERSRQLR   60
  61 QHRRESRPWPGRRGPPEGRRKRTAVTGSQTALLLRAFEKDRFPGIAAREELARETGLPES  120
 121 RIQIWFQNRRARHP
Interface Residues: 4, 7, 48, 49, 52, 53, 56, 57, 67, 73, 79, 80, 81, 82, 120, 121, 123, 124, 127, 128, 131, 132
3D-footprint Homologues: 3d1n_M, 5zfz_A, 2h8r_B, 1au7_A, 1ic8_B, 4j19_B, 2xsd_C, 7xrc_C, 8g87_X, 4xrm_B, 3l1p_A, 6m3d_C, 3a01_E, 1fjl_B, 3cmy_A, 6a8r_A, 2h1k_B, 1ig7_A, 1puf_A, 1jgg_B, 3lnq_A, 2lkx_A, 1zq3_P, 1nk2_P, 2ld5_A, 5flv_I, 1puf_B, 5zjt_E, 2hdd_A, 7psx_B, 1b72_A, 5hod_A, 3rkq_B, 2r5y_A, 2hos_A, 7q3o_C, 5jlw_D, 4cyc_A, 6es3_K, 4xrs_G, 1le8_A, 1e3o_C, 4qtr_D, 1du0_A
Binding Motifs: 6u82_D CTAATCTanTCA
Binding Sites: 6u82_E
			
Publications: Klingler C, Ashley J, Shi K, Stiefvater A, Kyba M, Sinnreich M, Aihara H, Kinter J. DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. FASEB J 34:4573-4590 (2020). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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