Transcription Factor
| Accessions: | Hoxd3_DBD (HumanTF 1.0), UP00241A (UniPROBE 20160601) |
| Names: | Homeobox protein Hox-4.1, Homeobox protein Hox-D3, Homeobox protein MH-19, Hoxd3, HXD3_MOUSE, homeo box D3, Hox-4.1, Hox-5.5, Hoxd-3, MH-19 |
| Organisms: | Mus musculus |
| Libraries: | HumanTF 1.0 1, UniPROBE 20160601 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] |
| Uniprot: | P09027 |
| Description: | homeo box D3: M.musculus Hoxd-3 mRNA |
| Notes: | Ensembl ID: ENSMUSG00000079277; DNA-binding domain sequence; TF family: homeodomain; Clone source: Hughes lab. |
| Length: | 93 |
| Pfam Domains: | 17-73 Homeobox domain |
| Sequence: (in bold interface residues) | 1 TSGENCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQI 60 61 KIWFQNRRMKYKKDQKAKGILHSPAGQSPERSP |
| Interface Residues: | 9, 17, 18, 19, 20, 58, 59, 61, 62, 65, 66, 69, 70, 73 |
| 3D-footprint Homologues: | 3a01_E, 6a8r_A, 2h1k_B, 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 1jgg_B, 3lnq_A, 2lkx_A, 6m3d_C, 3d1n_M, 1zq3_P, 7q3o_C, 5jlw_D, 6es3_K, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 5flv_I, 2hos_A, 1nk2_P, 1b72_A, 5zjt_E, 4cyc_A, 1ig7_A, 7psx_B, 5hod_A, 3l1p_A, 2ld5_A, 1e3o_C, 1le8_A, 7xrc_C, 1au7_A, 2xsd_C, 1o4x_A, 1du0_A, 4qtr_D, 1puf_B |
| Binding Motifs: | UP00241A_1 ytgrgkTAATTAmcst Hoxd3_DBD rsyaATTArs |
| Binding Sites: | GGTAATTA ACTAATTA AGTAATTA ATAATTAA ATAATTAC ATTAATGA ATTAATTA CGTAATTA CTAATTAA CTAATTAC CTAATTAG CTTAATTA GATAATTA GCTAATTA GTAATTAA GTAATTAC GTCATTAA GTTAATTA TAATTACA TTAATTAA |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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