Transcription Factor
| Accessions: | P17098 (JASPAR 2024) |
| Names: | Zinc finger protein 8, Zinc finger protein HF.18, ZNF8_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P17098 |
| Length: | 575 |
| Pfam Domains: | 25-65 KRAB box 256-277 C2H2-type zinc finger 257-279 C2H2-type zinc finger 257-279 Zinc finger, C2H2 type 271-295 Zinc-finger double domain 285-307 Zinc finger, C2H2 type 286-307 C2H2-type zinc finger 287-303 C2H2-type zinc finger 299-322 Zinc-finger double domain 312-333 C2H2-type zinc finger 313-335 Zinc finger, C2H2 type 327-351 Zinc-finger double domain 340-363 C2H2-type zinc finger 341-363 C2H2-type zinc finger 341-363 Zinc finger, C2H2 type 356-380 Zinc-finger double domain 368-389 C2H2-type zinc finger 369-391 C2H2-type zinc finger 369-391 Zinc finger, C2H2 type 387-408 Zinc-finger double domain 396-419 C2H2-type zinc finger 397-419 Zinc finger, C2H2 type 397-419 C2H2-type zinc finger 411-428 Zinc-finger double domain 458-476 Zinc-finger double domain 467-489 Zinc finger, C2H2 type 467-489 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MDPEDEGVAGVMSVGPPAARLQEPVTFRDVAVDFTQEEWGQLDPTQRILYRDVMLETFGH 60 61 LLSIGPELPKPEVISQLEQGTELWVAERGTTQGCHPAWEPRSESQASRKEEGLPEEEPSH 120 121 VTGREGFPTDAPYPTTLGKDRECQSQSLALKEQNNLKQLEFGLKEAPVQDQGYKTLRLRE 180 181 NCVLSSSPNPFPEISRGEYLYTYDSQITDSEHNSSLVSQQTGSPGKQPGENSDCHRDSSQ 240 241 AIPITELTKSQVQDKPYKCTDCGKSFNHNAHLTVHKRIHTGERPYMCKECGKAFSQNSSL 300 301 VQHERIHTGDKPYKCAECGKSFCHSTHLTVHRRIHTGEKPYECQDCGRAFNQNSSLGRHK 360 361 RTHTGEKPYTCSVCGKSFSRTTCLFLHLRTHTEERPYECNHCGKGFRHSSSLAQHQRKHA 420 421 GEKPFECRQRLIFEQTPALTKHEWTEALGCDPPLSQDERTHRSDRPFKCNQCGKCFIQSS 480 481 HLIRHQITHTREEQPHGRSRRREQSSSRNSHLVQHQHPNSRKSSAGGAKAGQPESRALAL 540 541 FDIQKIMQEKNPVHVIGVEEPSVGASMLFDIREST |
| Interface Residues: | 243, 257, 267, 268, 269, 270, 271, 274, 295, 296, 297, 298, 299, 301, 302, 303, 306, 323, 324, 325, 326, 327, 328, 329, 330, 331, 332, 333, 336, 351, 352, 353, 354, 355, 356, 357, 358, 361, 379, 380, 381, 382, 383, 385, 386, 390, 408, 409, 410, 411, 414, 417, 425, 428, 429, 451, 452, 453, 456, 462, 476, 478, 480, 481, 484, 488, 503, 504, 505, 506, 507, 525, 526, 535, 536 |
| 3D-footprint Homologues: | 5yel_A, 2kmk_A, 1tf3_A, 7w1m_H, 3uk3_C, 5ei9_F, 8gn3_A, 6e94_A, 6jnm_A, 8ssq_A, 5kkq_D, 5yj3_D, 8ssu_A, 5kl3_A, 2gli_A, 7txc_E, 1tf6_A, 6ml4_A, 5v3j_F, 4x9j_A, 4m9v_C, 7ysf_A, 6a57_A, 1ubd_C, 8cuc_F, 1g2f_F, 6blw_A, 6u9q_A, 2lt7_A, 2jpa_A, 7y3l_A, 7n5w_A, 1llm_D, 2drp_D, 1f2i_J, 5k5i_A, 2wbs_A, 8h9h_G, 8gh6_A, 7y3m_I, 5k5l_F, 3zqc_A, 5ciy_A |
| Binding Motifs: | MA1718.1 / UN0233.1 GTATrGATRTACCACAkTTT |
| Binding Sites: | MA1718.1.1 / UN0233.1.1 MA1718.1.10 / UN0233.1.10 MA1718.1.11 / UN0233.1.11 MA1718.1.12 / UN0233.1.12 UN0233.1.13 MA1718.1.13 / UN0233.1.14 MA1718.1.14 / UN0233.1.15 MA1718.1.15 / UN0233.1.16 MA1718.1.16 / UN0233.1.17 MA1718.1.17 / UN0233.1.18 MA1718.1.18 / UN0233.1.19 MA1718.1.2 / UN0233.1.2 UN0233.1.20 MA1718.1.3 / UN0233.1.3 MA1718.1.4 / UN0233.1.4 MA1718.1.5 / UN0233.1.5 MA1718.1.6 / UN0233.1.6 MA1718.1.7 / UN0233.1.7 MA1718.1.8 / UN0233.1.8 MA1718.1.9 / UN0233.1.9 MA1718.1.19 MA1718.1.20 |
| Publications: | Imbeault M, Helleboid PY, Trono D. KRAB zinc-finger proteins contribute to the evolution of gene regulatory networks. Nature 543:550-554 (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
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These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.