Transcription Factor
| Accessions: | HTF4_MOUSE (HOCOMOCO 10), Q61286 (JASPAR 2024) |
| Names: | Class A helix-loop-helix transcription factor ME1, DNA-binding protein HTF4, E-box-binding protein, HTF4_MOUSE, TCF-12, Transcription factor 12, Transcription factor HTF-4 |
| Organisms: | Mus musculus |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q61286 |
| Length: | 706 |
| Pfam Domains: | 602-655 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MNPQQQRMAAIGTDKELSDLLDFSAMFSPPVNSGKTRPTTLGSSQFSGSGMDERGGTTSW 60 61 GTSGQPSPSYDSSRGFTDSPHYSDHLNDSRLGTHEGLSPTPFMNSNLIGKTSERGSFSLY 120 121 SRDSGLSGCQSSLLRQDLGLGSPAQLSSSGKPGTPYYSFSATSSRRRPLHDSVALDPLQA 180 181 KKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHSSSDLWSS 240 241 SNGMSQPGFGGILGTSTSHMSQSSSYGSLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRG 300 301 STSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSPDHTSSSFPSNP 360 361 STPVGSPSPLTGTSQWPRAGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCE 420 421 QSRMEDRLDRLDDAIHVLRNHAVGPSTSLPTSHSDIHSLLGPSHNASIGNLNSNYGGSSL 480 481 VTNSRSASMVGTHREDSVSLNGNHSVLSSTVAASNTELNHKTPENFRGGVQNQSGSVVPT 540 541 EIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREK 600 601 ERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLILHQAVAVILSLEQQVRE 660 661 RNLNPKAACLKRREEEKVSAASAEPPNTLPGAHPGLSESTNPMGHL |
| Interface Residues: | 603, 606, 607, 609, 610, 611, 613, 614 |
| 3D-footprint Homologues: | 2ypa_A, 7z5k_B, 7d8t_A, 6g1l_A, 6od3_F, 2ypa_B, 2ql2_A, 2ql2_D |
| Binding Motifs: | MA0521.1 rRCAGCTGswg HTF4_MOUSE.H10MO.C|M01152 rrsrrCAGCTG MA0521.2 gvaCAGCTGtbs MA0521.3 CAGCTG |
| Binding Sites: | MA0521.3.20 MA0521.3.1 / MA0521.3.10 / MA0521.3.13 / MA0521.3.14 / MA0521.3.15 / MA0521.3.16 / MA0521.3.17 / MA0521.3.18 / MA0521.3.2 / MA0521.3.3 / MA0521.3.4 / MA0521.3.5 / MA0521.3.6 / MA0521.3.7 / MA0521.3.8 / MA0521.3.9 MA0521.3.19 MA0521.1.16 MA0521.1.17 MA0521.1.2 MA0521.1.3 MA0521.1.4 MA0521.1.5 MA0521.1.15 MA0521.1.1 MA0521.1.10 MA0521.1.11 MA0521.1.12 MA0521.1.13 MA0521.1.14 MA0521.1.18 MA0521.1.19 MA0521.1.20 MA0521.1.6 MA0521.1.7 MA0521.1.8 MA0521.1.9 MA0521.2.1 MA0521.2.10 / MA0521.2.14 MA0521.2.11 MA0521.2.12 MA0521.2.13 / MA0521.2.15 MA0521.2.14 / MA0521.2.16 MA0521.2.15 / MA0521.2.17 MA0521.2.16 / MA0521.2.18 MA0521.2.17 / MA0521.2.19 MA0521.2.18 / MA0521.2.20 MA0521.2.19 MA0521.2.2 MA0521.2.20 MA0521.2.3 / MA0521.2.5 MA0521.2.4 / MA0521.2.6 MA0521.2.5 / MA0521.2.7 MA0521.2.6 / MA0521.2.8 MA0521.2.11 / MA0521.2.7 MA0521.2.12 / MA0521.2.8 MA0521.2.13 / MA0521.2.9 MA0521.2.10 MA0521.2.3 MA0521.2.4 MA0521.2.9 MA0521.3.11 MA0521.3.12 |
| Publications: | Zhang Y, Doyle K, Bina M. Interactions of HTF4 with E-box motifs in the long terminal repeat of human immunodeficiency virus type 1. Journal of virology 66:5631-4 (1992). [Pubmed] |
| Related annotations: | PaperBLAST |
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