Transcription Factor
| Accessions: | T093248_1.02 (CISBP 1.02), O43364 (JASPAR 2024) |
| Names: | HOXA2, T093248_1.02;, Homeobox protein Hox-1K, Homeobox protein Hox-A2, HXA2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Notes: | experiment type:PBM, family:Homeodomain |
| Length: | 376 |
| Pfam Domains: | 144-200 Homeobox domain |
| Sequence: (in bold interface residues) | 1 MNYEFEREIGFINSQPSLAECLTSFPPVADTFQSSSIKTSTLSHSTLIPPPFEQTIPSLN 60 61 PGSHPRHGAGGRPKPSPAGSRGSPVPAGALQPPEYPWMKEKKAAKKTALLPAAAAAATAA 120 121 ATGPACLSHKESLEIADGSGGGSRRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALL 180 181 DLTERQVKVWFQNRRMKHKRQTQCKENQNSEGKCKSLEDSEKVEEDEEEKTLFEQALSVS 240 241 GALLEREGYTFQQNALSQQQAPNGHNGDSQSFPVSPLTSNEKNLKHFQHQSPTVPNCLST 300 301 MGQNCGAGLNNDSPEALEVPSLQDFSVFSTDSCLQLSDAVSPSLPGSLDSPVDISADSLD 360 361 FFTDTLTTIDLQHLNY |
| Interface Residues: | 144, 145, 146, 147, 185, 186, 188, 189, 192, 193, 196, 197, 200 |
| 3D-footprint Homologues: | 1puf_A, 3cmy_A, 5zfz_A, 1fjl_B, 3d1n_M, 6a8r_A, 2h1k_B, 3lnq_A, 2lkx_A, 1nk2_P, 1zq3_P, 1jgg_B, 6es3_K, 2ld5_A, 7q3o_C, 5jlw_D, 4xrs_G, 2hdd_A, 3rkq_B, 2r5y_A, 1puf_B, 6m3d_C, 5flv_I, 2hos_A, 1b72_A, 5zjt_E, 4cyc_A, 1ig7_A, 7psx_B, 5hod_A, 3a01_E, 1e3o_C, 1le8_A, 7xrc_C, 1au7_A, 2xsd_C, 8g87_X, 3l1p_A, 1o4x_A, 1du0_A, 4qtr_D |
| Binding Motifs: | MA0900.1 ssymATTAsc M0887_1.02 yytraykas MA0900.2 sTMATTAs MA0900.3 TMATTA |
| Publications: | Berger M.F, Badis G, Gehrke A.R, Talukder S, Philippakis A.A, Peña-Castillo L, Alleyne T.M, Mnaimneh S, Botvinnik O.B, Chan E.T, Khalid F, Zhang W, Newburger D, Jaeger S.A, Morris Q.D, Bulyk M.L, Hughes T.R. Variation in homeodomain DNA binding revealed by high-resolution analysis of sequence preferences. Cell 133:1266-76 (2008). [Pubmed] |
| Related annotations: | PaperBLAST |
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