Transcription Factor
| Accessions: | OTX2_DBD (HumanTF 1.0) |
| Names: | Homeobox protein OTX2, Orthodenticle homolog 2, OTX2, OTX2_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Uniprot: | P32243 |
| Notes: | Ensembl ID: ENSG00000165588; DNA-binding domain sequence; TF family: homeodomain; Clone source: hDBD_G |
| Length: | 128 |
| Pfam Domains: | 45-101 Homeobox domain |
| Sequence: (in bold interface residues) | 1 SYLKQPPYAVNGLSLTTSGMDLLHPSVGYPGPWASCPAATPRKQRRERTTFTRAQLDVLE 60 61 ALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQQNGGQNKVRPAKKK 120 121 TSPAREVS |
| Interface Residues: | 40, 42, 44, 45, 46, 47, 48, 86, 87, 89, 90, 93, 94, 97, 98, 101 |
| 3D-footprint Homologues: | 6m3d_C, 4j19_B, 1ig7_A, 2h1k_B, 1puf_A, 6a8r_A, 3cmy_A, 3d1n_M, 1fjl_B, 5zfz_A, 3lnq_A, 2lkx_A, 1jgg_B, 1nk2_P, 1zq3_P, 2ld5_A, 1b72_A, 5flv_I, 3l1p_A, 5zjt_E, 3a01_E, 7psx_B, 5hod_A, 2hdd_A, 7q3o_C, 5jlw_D, 3rkq_B, 2r5y_A, 1puf_B, 6es3_K, 1au7_A, 4xrs_G, 2hos_A, 4cyc_A, 1e3o_C, 7xrc_C, 2xsd_C, 1le8_A, 1o4x_A, 8g87_X, 1le8_B, 1du0_A, 4qtr_D, 1mnm_C, 1k61_B |
| Binding Motifs: | OTX2_DBD_1 kwTAATCCGmTTAwm OTX2_DBD_2 tTAATCCb |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] |
| Related annotations: | PaperBLAST |
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