Transcription Factor

						

			
Accessions: CREB3L1_full (HumanTF 1.0), CREB3L1_TF1 (HumanTF2 1.0), CREB3L1_TF2 (HumanTF2 1.0)

			
Names: B2RA75_HUMAN, cDNA, FLJ94739, highly similar to Homo sapiens cAMP responsive element binding protein 3-like 1, CREB3L1
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: B2RA75
Notes: Ensembl ID: ENSG00000157613; Full protein sequence; TF family: bZIP; Clone source: hORFeome, Ensembl ID: ENSG00000157613; Construct type: TF1(SBP); TF family: bZIP; Clone source: Jolma et al. 2013, Ensembl ID: ENSG00000157613; Construct type: TF2(3xFLAG); TF family: bZIP; Clone source: Jolma et al. 2013
Length: 520
Pfam Domains:   288-350 bZIP transcription factor
  291-341 Basic region leucine zipper
Sequence: 
(in bold interface residues)		   1 MDAVLEPFPADRLFPGSSFLDLGDLNESDFLNNAHFPEHLDHFTENMEDFSNDLFSSFFD   60
  61 DPVLDEKSPLLDMELDSPTPGIQAEHSYSLSGDSAPQSPLVPIKMEDTTQDAEHGAWALG  120
 121 HKLCSIMVKQEQSPELPVDPLAAPSAMAAAAAMATTPLLGLSPLSRLPIPHQAPGEMTQL  180
 181 PVIKAEPLEVNQFLKVTPEDLVQMPPTPPSSHGSDSDGSQSPRSLPPSSPVRPMARSSTA  240
 241 ISTSPLLTAPHKLQGTSGPLLLTEEEKRTLIAEGYPIPTKLPLTKAEEKALKRVRRKIKN  300
 301 KISAQESRRKKKEYVECLEKKVETFTSENNELWKKVETLENANRTLLQQLQKLQTLVTNK  360
 361 ISRPYKMAATQTGTCLMVAALCFVLVLGSLVPCLPEFSSGSQTVKEDPLAADGVYTASQM  420
 421 PSRSLLFYDDGAGLWEDGRSTLLPMEPPDGWEINPGGPAEQRPRDHLQHDHLDSTHETTK  480
 481 YLSEAWPKDGGNGTSPDFSHSKEWFHDRDLGPNTTIKLS*
Interface Residues: 208, 210, 296, 297, 300, 301, 303, 304, 306, 307, 308, 310, 311
3D-footprint Homologues: 2nra_C, 7x5e_F, 1skn_P, 7x5e_E, 1nwq_C, 6mg1_B, 5vpe_D, 7z5k_B, 2dgc_A, 1dh3_C, 5t01_B
Binding Motifs: CREB3L1_full_1 TGCCACGTGGCA
CREB3L1_full_2 rTGCCACGTCAyCA
CEBPG_CREB3L1 tGCcACGCAAym
			
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]


Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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