Transcription Factor
Accessions: | 1ruo_B (3D-footprint 20231221) |
Names: | cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, Catabolite activator protein, CATABOLITE GENE ACTIVATOR PROTEIN (CAP), CRP_ECOLI |
Organisms: | Escherichia coli, strain K12 |
Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
Uniprot: | P0ACJ8 |
Length: | 201 |
Pfam Domains: | 14-102 Cyclic nucleotide-binding domain 133-197 Crp-like helix-turn-helix domain 157-188 Bacterial regulatory proteins, crp family |
Sequence: (in bold interface residues) | 1 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGD 60 61 FIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTS 120 121 EKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRFTVGRILK 180 181 MLEDQNLISAHGKTIVVYGTR |
Interface Residues: | 18, 72, 157, 162, 171, 172, 173, 174, 176, 177 |
3D-footprint Homologues: | 3iyd_H, 4a12_B, 2xro_E, 3mzh_A, 7pza_B, 3e6c_C, 4i2o_B, 5i2d_R |
Binding Motifs: | 1ruo_B TgtGA |
Binding Sites: | 1ruo_D 1ruo_E |
Publications: | Parkinson G, Gunasekera A, Vojtechovsky J, Zhang X, Kunkel T.A, Berman H, Ebright R.H. Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nature structural biology 3:837-41 (1996). [Pubmed] |
Related annotations: | PaperBLAST |
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