Transcription Factor

						

			
Accessions: 1ruo_B (3D-footprint 20231221)

			
Names: cAMP receptor protein, cAMP regulatory protein, cAMP-activated global transcriptional regulator CRP, Catabolite activator protein, CATABOLITE GENE ACTIVATOR PROTEIN (CAP), CRP_ECOLI
Organisms: Escherichia coli, strain K12
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P0ACJ8
Length: 201
Pfam Domains:    14-102 Cyclic nucleotide-binding domain
  133-197 Crp-like helix-turn-helix domain
  157-188 Bacterial regulatory proteins, crp family
Sequence: 
(in bold interface residues)		   1 PTLEWFLSHCHIHKYPSKSTLIHQGEKAETLYYIVKGSVAVLIKDEEGKEMILSYLNQGD   60
  61 FIGELGLFEEGQERSAWVRAKTACEVAEISYKKFRQLIQVNPDILMRLSAQMARRLQVTS  120
 121 EKVGNLAFLDVTGRIAQTLLNLAKQPDAMTHPDGMQIKITRQEIGQIVGCSRFTVGRILK  180
 181 MLEDQNLISAHGKTIVVYGTR
Interface Residues: 18, 72, 157, 162, 171, 172, 173, 174, 176, 177
3D-footprint Homologues: 3iyd_H, 4a12_B, 2xro_E, 3e6c_C, 4i2o_B, 5i2d_R, 3mzh_A, 7pza_B
Binding Motifs: 1ruo_B TgtGA
Binding Sites: 1ruo_D
1ruo_E
			
Publications: Parkinson G, Gunasekera A, Vojtechovsky J, Zhang X, Kunkel T.A, Berman H, Ebright R.H. Aromatic hydrogen bond in sequence-specific protein DNA recognition. Nature structural biology 3:837-41 (1996). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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