Transcription Factor
| Accessions: | T146243_1.02 (CISBP 1.02), UP00352A (UniPROBE 20160601), P11632 (JASPAR 2024), 1j5n_A (3D-footprint 20231221) |
| Names: | NHP6A, T146243_1.02;, NHPA, Nonhistone chromosomal protein 6A, YP9499.09C, YPR052C, NHP6A_YEAST |
| Organisms: | Saccharomyces cerevisiae, Saccharomyces cerevisiae (strain ATCC 204508 / S288c) |
| Libraries: | CISBP 1.02 1, UniPROBE 20160601 2, JASPAR 2024 3, 3D-footprint 20231221 4 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Hume MA, Barrera LA, Gisselbrecht SS, Bulyk ML. UniPROBE, update 2015: new tools and content for the online database of protein-binding microarray data on protein-DNA interactions. Nucleic Acids Res : (2015). [Pubmed] 3 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] 4 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Description: | High-mobility group non-histone chromatin protein, functionally redundant with Nhp6Bp; homologous to mammalian high mobility group proteins 1 and 2; acts to recruit transcription factor Rcs1p to ce... |
| Notes: | experiment type:PBM, family:Sox |
| Length: | 93 |
| Pfam Domains: | 18-84 Domain of unknown function (DUF1898) 21-89 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 MVTPREPKKRTTRKKKDPNAPKRALSAYMFFANENRDIVRSENPDITFGQVGKKLGEKWK 60 61 ALTPEEKQPYEAKAQADKKRYESEKELYNATLA |
| Interface Residues: | 3, 8, 10, 11, 13, 23, 26, 28, 29, 32, 36, 47, 48, 49, 52 |
| 3D-footprint Homologues: | 1j5n_A, 2gzk_A, 4y60_C, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 3tmm_A, 3tq6_B, 1hry_A, 1ckt_A, 7zie_A |
| Binding Motifs: | MA0345.1 mtkwhywmTATATAawwwwrh UP00352A_1 mtkwhywmTATATAawwwwrh M1615_1.02 hyAywawr 1j5n_A AACAATc |
| Binding Sites: | AATATAAT AATATATA ATAATAAT ATAATTAA ATATAATA ATATATAA ATATTATA ATTATATA CTATATAA TAATATAA TAATTATA TATATAAA TATATAGA TATATATA TTAATTAA TTATATAA 1j5n_B 1j5n_C ACTATAGT ATAGTATA ATTATTAA TATAGTAA |
| Publications: | *Zhu C, *Byers K, *McCord RP, Shi Z, Berger MF, Newburger D, Saulrieta K, Smith Z, Shah M, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A , Murthy TVS, LaBaer J, Bulyk ML. High-Resolution DNA Binding Specificity Analysis of Yeast Transcription Factors. Genome Research. Epub January 21, 2009, doi:10.1101/gr.090233.108 (*co-1st authors). [Pubmed] Newburger D.E, Bulyk M.L. UniPROBE: an online database of protein binding microarray data on protein-DNA interactions. Nucleic acids research 37:D77-82 (2009). [Pubmed] Masse J.E, Wong B, Yen Y.M, Allain F.H, Johnson R.C, Feigon J. The S. cerevisiae architectural HMGB protein NHP6A complexed with DNA: DNA and protein conformational changes upon binding. Journal of molecular biology 323:263-84 (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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