Transcription Factor
| Accessions: | AP2C_HUMAN (HOCOMOCO 10), Q92754 (JASPAR 2024) |
| Names: | Activating enhancer-binding protein 2 gamma, AP2-gamma, AP2C_HUMAN, Transcription factor AP-2 gamma, Transcription factor ERF-1 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 450 |
| Pfam Domains: | 220-427 Transcription factor AP-2 |
| Sequence: (in bold interface residues) | 1 MLWKITDNVKYEEDCEDRHDGSSNGNPRVPHLSSAGQHLYSPAPPLSHTGVAEYQPPPYF 60 61 PPPYQQLAYSQSADPYSHLGEAYAAAINPLHQPAPTGSQQQAWPGRQSQEGAGLPSHHGR 120 121 PAGLLPHLSGLEAGAVSARRDAYRRSDLLLPHAHALDAAGLAENLGLHDMPHQMDEVQNV 180 181 DDQHLLLHDQTVIRKGPISMTKNPLNLPCQKELVGAVMNPTEVFCSVPGRLSLLSSTSKY 240 241 KVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRSLREKLDKIGLNLPAGRRKAAHVT 300 301 LLTSLVEGEAVHLARDFAYVCEAEFPSKPVAEYLTRPHLGGRNEMAARKNMLLAAQQLCK 360 361 EFTELLSQDRTPHGTSRLAPVLETNIQNCLSHFSLITHGFGSQAICAAVSALQNYIKEAL 420 421 IVIDKSYMNPGDQSPADSNKTLEKMEKHRK |
| Interface Residues: | 235, 269, 270 |
| 3D-footprint Homologues: | 8j0k_B |
| Binding Motifs: | MA0524.2 tGCCyyrrGGCa MA0814.1 hGCCtsAGGCw MA0815.1 tGCCCysrGGGCa MA0524.1 hmydsCCyCAGGsca AP2C_HUMAN.H10MO.A|M01009 rtgsCCTGrGGsma MA0814.2 bggCCTGAGGCgvs MA0524.3 GCCyyrrGGCa MA0814.3 gCCTGAGGC |
| Binding Sites: | MA0524.1.2 MA0524.1.18 MA0524.1.15 MA0524.1.17 MA0524.1.1 MA0524.1.10 MA0524.1.11 / MA0524.1.13 / MA0524.1.19 MA0524.1.12 MA0524.1.14 MA0524.1.16 MA0524.1.20 MA0524.1.3 MA0524.1.4 MA0524.1.5 MA0524.1.6 MA0524.1.7 MA0524.1.8 MA0524.1.9 MA0814.2.1 MA0814.2.10 MA0814.2.11 MA0814.2.12 / MA0814.2.4 MA0814.2.13 MA0814.2.14 MA0814.2.15 MA0814.2.16 MA0814.2.17 / MA0814.2.5 MA0814.2.18 / MA0814.2.6 MA0814.2.19 MA0814.2.1 / MA0814.2.2 MA0814.2.20 / MA0814.2.7 MA0814.2.3 MA0814.2.4 MA0814.2.2 / MA0814.2.5 MA0814.2.6 MA0814.2.3 / MA0814.2.7 MA0814.2.8 MA0814.2.9 MA0814.2.10 MA0814.2.11 MA0814.2.12 MA0814.2.13 MA0814.2.14 MA0814.2.15 MA0814.2.16 MA0814.2.17 MA0814.2.18 MA0814.2.19 MA0814.2.20 MA0814.2.8 MA0814.2.9 MA0814.3.20 MA0814.3.19 / MA0814.3.2 MA0814.3.1 MA0814.3.10 / MA0814.3.12 MA0814.3.11 MA0814.3.13 MA0814.3.14 MA0814.3.15 MA0814.3.16 MA0814.3.17 MA0814.3.18 / MA0814.3.6 MA0814.3.3 MA0814.3.4 MA0814.3.5 MA0814.3.7 MA0814.3.8 MA0814.3.9 |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Woodfield G.W, Chen Y, Bair T.B, Domann F.E, Weigel R.J. Identification of primary gene targets of TFAP2C in hormone responsive breast carcinoma cells. Genes, chromosomes & cancer 49:948-62 (2010). [Pubmed] Eckert D, Buhl S, Weber S, Jäger R, Schorle H. The AP-2 family of transcription factors. Genome Biol : (2005;6(13):246.). [Pubmed] |
| Related annotations: | PaperBLAST |
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