Transcription Factor

						

			
Accessions: 6qhd_A (3D-footprint 20231221)

			
Names: Acute-phase response factor, Signal transducer and activator of transcription 3, STAT3_HUMAN
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: P40763
Length: 528
Pfam Domains:     4-175 STAT protein, all-alpha domain
  177-418 STAT protein, DNA binding domain
  428-486 SH2 domain
Sequence: 
(in bold interface residues)		   1 VVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDSVTRQKMQQLE   60
  61 QMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLE  120
 121 NWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVE  180
 181 RQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKF  240
 241 NILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCASLIVTEELHLITFETEVYHQGLKID  300
 301 LETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFS  360
 361 STTKRGLSIEQLTTLAEKLLGPYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYI  420
 421 LALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEQIQSVEPYTKQ  480
 481 QLNNMSFAEIIMGYLVSPLVYLYPDIPKEEAFGYCRAPLKTKFICVTP
Interface Residues: 196, 312, 313, 314, 315, 316
3D-footprint Homologues: 1bf5_A, 1bg1_A, 4y5w_B
Binding Motifs: 6qhd_A GGAA
6qhd_AB TTACsGGAA
Binding Sites: 6qhd_C
6qhd_D
			
Publications: Belo Y, Mielko Z, Nudelman H, Afek A, Ben-David O, Shahar A, Zarivach R, Gordan R, Arbely E. Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. Biochim Biophys Acta Gen Subj 1863:1343-1350 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
Disclaimer and license


These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.