Transcription Factor
| Accessions: | P52738 (JASPAR 2024) |
| Names: | ZN140_HUMAN |
| Organisms: | Homo sapiens |
| Libraries: | JASPAR 2024 1 1 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | P52738 |
| Length: | 457 |
| Pfam Domains: | 6-46 KRAB box 147-171 Zinc-finger double domain 161-183 Zinc finger, C2H2 type 161-183 C2H2-type zinc finger 163-183 C2H2-type zinc finger 176-199 Zinc-finger double domain 189-211 Zinc finger, C2H2 type 189-211 C2H2-type zinc finger 189-207 C2H2-type zinc finger 203-228 Zinc-finger double domain 216-239 C2H2-type zinc finger 217-239 Zinc finger, C2H2 type 234-256 Zinc-finger double domain 244-265 C2H2-type zinc finger 245-267 Zinc finger, C2H2 type 245-267 C2H2-type zinc finger 259-284 Zinc-finger double domain 273-295 C2H2-type zinc finger 273-295 Zinc finger, C2H2 type 273-295 C2H2-type zinc finger 288-311 Zinc-finger double domain 300-320 C2H2-type zinc finger 301-323 C2H2-type zinc finger 301-323 Zinc finger, C2H2 type 315-339 Zinc-finger double domain 328-349 C2H2-type zinc finger 346-367 Zinc-finger double domain 356-379 C2H2-type zinc finger 357-379 C2H2-type zinc finger 357-379 Zinc finger, C2H2 type 372-396 Zinc-finger double domain 385-407 C2H2-type zinc finger 385-407 C2H2-type zinc finger 385-407 Zinc finger, C2H2 type 402-423 Zinc-finger double domain 413-435 Zinc finger, C2H2 type 413-435 C2H2-type zinc finger 413-435 C2H2-type zinc finger |
| Sequence: (in bold interface residues) | 1 MSQGSVTFRDVAIDFSQEEWKWLQPAQRDLYRCVMLENYGHLVSLGLSISKPDVVSLLEQ 60 61 GKEPWLGKREVKRDLFSVSESSGEIKDFSPKNVIYDDSSQYLIMERILSQGPVYSSFKGG 120 121 WKCKDHTEMLQENQGCIRKVTVSHQEALAQHMNISTVERPYGCHECGKTFGRRFSLVLHQ 180 181 RTHTGEKPYACKECGKTFSQISNLVKHQMIHTGKKPHECKDCNKTFSYLSFLIEHQRTHT 240 241 GEKPYECTECGKAFSRASNLTRHQRIHIGKKQYICRKCGKAFSSGSELIRHQITHTGEKP 300 301 YECIECGKAFRRFSHLTRHQSIHTTKTPYECNECRKAFRCHSFLIKHQRIHAGEKLYECD 360 361 ECGKVFTWHASLIQHTKSHTGEKPYACAECDKAFSRSFSLILHQRTHTGEKPYVCKVCNK 420 421 SFSWSSNLAKHQRTHTLDNPYEYENSFNYHSFLTEHQ |
| Interface Residues: | 161, 172, 173, 174, 175, 177, 178, 179, 180, 181, 184, 199, 200, 201, 202, 203, 204, 205, 206, 207, 227, 228, 229, 230, 231, 233, 234, 255, 256, 257, 258, 259, 261, 262, 265, 283, 284, 285, 286, 287, 289, 290, 311, 312, 313, 314, 315, 317, 318, 340, 341, 342, 343, 344, 346, 349, 350, 367, 368, 369, 370, 371, 374, 380, 394, 395, 396, 397, 398, 399, 402, 406, 423, 424, 425, 426, 427, 429, 430, 433, 434 |
| 3D-footprint Homologues: | 2kmk_A, 7w1m_H, 4m9v_C, 2jpa_A, 6jnm_A, 1tf6_A, 5ei9_F, 1g2f_F, 5kl3_A, 2drp_D, 6blw_A, 4x9j_A, 7y3l_A, 8ssu_A, 8gn3_A, 6ml4_A, 5v3j_F, 8ssq_A, 6u9q_A, 6e94_A, 7ysf_A, 5yel_A, 5yj3_D, 5k5l_F, 2lt7_A, 2gli_A, 5kkq_D, 5k5i_A, 1ubd_C, 7n5w_A, 1tf3_A, 7txc_E, 8h9h_G, 6a57_A, 3uk3_C, 8cuc_F, 1f2i_J, 2wbs_A, 1llm_D, 7y3m_I |
| Binding Motifs: | MA1589.1 tagGAGyrGAATTGCTgggtc MA1589.2 agGAGyrGAATTGCTgggt |
| Binding Sites: | MA1589.1.1 MA1589.1.10 / MA1589.1.9 MA1589.1.10 / MA1589.1.11 MA1589.1.11 / MA1589.1.12 MA1589.1.12 / MA1589.1.13 MA1589.1.13 / MA1589.1.14 MA1589.1.14 / MA1589.1.15 MA1589.1.15 / MA1589.1.16 MA1589.1.17 MA1589.1.16 / MA1589.1.18 MA1589.1.17 / MA1589.1.19 MA1589.1.2 MA1589.1.18 / MA1589.1.20 MA1589.1.3 MA1589.1.4 MA1589.1.5 MA1589.1.6 MA1589.1.7 MA1589.1.8 MA1589.1.9 MA1589.1.19 MA1589.1.20 MA1589.2.1 MA1589.2.10 MA1589.2.11 MA1589.2.12 MA1589.2.13 MA1589.2.14 MA1589.2.15 MA1589.2.16 MA1589.2.17 MA1589.2.18 MA1589.2.19 MA1589.2.2 MA1589.2.20 MA1589.2.3 MA1589.2.4 MA1589.2.5 MA1589.2.6 MA1589.2.7 MA1589.2.8 MA1589.2.9 |
| Publications: | Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Related annotations: | PaperBLAST |
Disclaimer and license
These data are available AS IS and at your own risk. The EEAD/CSIC do not give any representation or warranty nor assume any liability or responsibility for the data nor the results posted (whether as to their accuracy, completeness, quality or otherwise). Access to these data is available free of charge for ordinary use in the course of research. Downloaded data have CC-BY-NC-SA license. FootprintDB is also available at RSAT::Plants, part of the INB/ELIXIR-ES resources portfolio.