Transcription Factor
| Accessions: | ERG (HT-SELEX2 May2017) |
| Names: | ENSG00000157554, ERG |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: ETS experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: ETS experiment: HT-SELEX Hamming distance: 1 cycle: 3, TF family: ETS experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 3 |
| Length: | 300 |
| Pfam Domains: | 20-102 Sterile alpha motif (SAM)/Pointed domain 191-273 Ets-domain |
| Sequence: (in bold interface residues) | 1 SPDTVGMNYGSYMEEKHMPPPNMTTNERRVIVPADPTLWSTDHVRQWLEWAVKEYGLPDV 60 61 NILLFQNIDGKELCKMTKDDFQRLTPSYNADILLSHLHYLRETPLPHLTSDDVDKALQNS 120 121 PRLMHARNTDLPYEPPRRSAWTGHGHPTPQSKAAQPSPSTVPKTEDQRPQLDPYQILGPT 180 181 SSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPN 240 241 MNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMG 300 |
| Interface Residues: | 189, 244, 245, 247, 248, 249, 251, 252, 266 |
| 3D-footprint Homologues: | 3zp5_A, 8ee9_F, 4mhg_A, 2stt_A, 4uno_A, 3jtg_A, 1dux_F, 7jsa_J, 1yo5_C, 4bqa_A, 1awc_A, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B |
| Binding Motifs: | ERG_3 raCCGGAWrys ERG_4 raCCGGAwwTCCGGty ERG_7 grCCGGAwrys ERG_8 gACCGGATATCCGGTc ERG_methyl_1 aaCAGGAAryg ERG_methyl_2 rACCGGATATCCGGTy ERG_methyl_5 raCmGGAWrTs ERG_methyl_6 raCCGGAwwTCCGGth |
| Related annotations: | PaperBLAST |
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