Transcription Factor
| Accessions: | 4nnu_A (3D-footprint 20231221), 6hb4_G (3D-footprint 20231221), 6hb4_J (3D-footprint 20231221) |
| Names: | Mitochondrial transcription factor 1, MtTF1, mtTFA, TCF-6, TFAM_HUMAN, Transcription factor 6, Transcription factor 6-like 2, Transcription factor A, mitochondrial |
| Organisms: | Homo sapiens |
| Libraries: | 3D-footprint 20231221 1 1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed] |
| Uniprot: | Q00059 |
| Length: | 193 |
| Pfam Domains: | 7-69 Domain of unknown function (DUF1898) 7-75 HMG (high mobility group) box 111-172 Domain of unknown function (DUF1898) 112-175 HMG (high mobility group) box |
| Sequence: (in bold interface residues) | 1 SVLASCPKKPVSSYLRFSKEQLPIFKAQNPDAKTTELIRRIAQRWRELPDSKKKIYQDAY 60 61 RAEWQVYKEEISRFKEQLTPSQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYN 120 121 VYVAERFQEAKGDSPQEKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWEEQMI 180 181 EVGRKDLLRRTIK |
| Interface Residues: | 9, 12, 14, 15, 18, 22, 33, 34, 35, 38, 96, 97, 98, 100, 103, 104, 114, 119, 120, 123, 127, 135, 136, 139 |
| 3D-footprint Homologues: | 6jrp_D, 1qrv_A, 2gzk_A, 3u2b_C, 1j5n_A, 3f27_D, 4y60_C, 1o4x_B, 3tmm_A, 3tq6_B, 1hry_A, 7zie_A, 1ckt_A |
| Binding Motifs: | 4nnu_AB TCCCGnnnnnnAACTTnnnnGnTCCCnnnnnnnAACTT 6hb4_ADGJ AATTGAnnnnnnnCACAnnnnnAATTGAnnnnnnnCACAGnnnnnATTGAnnnnnnnCACAGnnnnAATTGAnnnnnnnCACAG 6hb4_J AATTGAnnnnnnnnACAG |
| Publications: | Ngo H.B, Lovely G.A, Phillips R, Chan D.C. Distinct structural features of TFAM drive mitochondrial DNA packaging versus transcriptional activation. Nature communications 5:3077 (2014). [Pubmed] Cuppari A, Fernández-Millán P, Battistini F, Tarrés-Solé A, Lyonnais S, Iruela G, Ruiz-López E, Enciso Y, Rubio-Cosials A, Prohens R, Pons M, Alfonso C, Tóth K, Rivas G, Orozco M, Solà M. DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region. Nucleic Acids Res 47:6519-6537 (2019). [Pubmed] |
| Related annotations: | PaperBLAST |
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