Transcription Factor
| Accessions: | TCF7L1 (HT-SELEX2 May2017) |
| Names: | ENSG00000152284, TCF7L1 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: HMG experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: HMG experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 106 |
| Pfam Domains: | 21-88 HMG (high mobility group) box 22-81 Domain of unknown function (DUF1898) |
| Sequence: (in bold interface residues) | 1 PAVSVKSPVTVKKEEEKKPHVKKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRKWH 60 61 NLSREEQAKYYELARKERQLHSQLYPTWSARDNYGKKKKRKREKQL |
| Interface Residues: | 4, 11, 12, 14, 23, 26, 28, 29, 32, 36, 47, 48, 49, 52, 90, 92, 93, 94, 97 |
| 3D-footprint Homologues: | 1j5n_A, 4y60_C, 3f27_D, 7m5w_A, 1o4x_B, 3u2b_C, 2gzk_A, 4s2q_D, 2lef_A, 1hry_A, 8a5p_G |
| Binding Motifs: | TCF7L1_2 asATCAAAG TCF7L1_methyl_1 AsATCAAAG |
| Related annotations: | PaperBLAST |
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