Transcription Factor

						

			
Accessions: ZNF33A (humanC2H2ZF-ChIP Feb2015)

			
Names: ENSG00000189180, Q06730, ZNF33A
Organisms: Homo sapiens
Libraries: humanC2H2ZF-ChIP Feb2015 1
1 Najafabadi HS, Mnaimneh S, Schmitges FW, Garton M, Lam KN, Yang A, Albu M, Weirauch MT, Radovani E, Kim PM, Greenblatt J, Frey BJ, Hughes TR. C2H2 zinc finger proteins greatly expand the human regulatory lexicon. Nat Biotechnol 33:555-62 (2015). [Pubmed]
Notes: TF family: C2H2;KRAB experiment: ChIP-seq/MEME/B1H-RC
Length: 810
Pfam Domains:     12-52 KRAB box
  140-152 C2H2-type zinc finger
  328-337 C2H2-type zinc finger
  328-350 Zinc finger, C2H2 type
  328-350 C2H2-type zinc finger
  342-366 Zinc-finger double domain
  356-378 C2H2-type zinc finger
  356-378 Zinc finger, C2H2 type
  356-378 C2H2-type zinc finger
  370-395 Zinc-finger double domain
  384-406 C2H2-type zinc finger
  384-406 Zinc finger, C2H2 type
  384-406 C2H2-type zinc finger
  398-421 Zinc-finger double domain
  412-434 Zinc finger, C2H2 type
  412-434 C2H2-type zinc finger
  412-434 C2H2-type zinc finger
  426-449 Zinc-finger double domain
  439-450 C2H2-type zinc finger
  440-462 Zinc finger, C2H2 type
  440-462 C2H2-type zinc finger
  454-478 Zinc-finger double domain
  468-488 C2H2-type zinc finger
  468-490 Zinc finger, C2H2 type
  468-490 C2H2-type zinc finger
  482-507 Zinc-finger double domain
  496-505 C2H2-type zinc finger
  496-518 Zinc finger, C2H2 type
  496-518 C2H2-type zinc finger
  511-533 Zinc-finger double domain
  523-546 C2H2-type zinc finger
  524-546 Zinc finger, C2H2 type
  524-546 C2H2-type zinc finger
  538-563 Zinc-finger double domain
  552-574 Zinc finger, C2H2 type
  552-574 C2H2-type zinc finger
  567-591 Zinc-finger double domain
  579-592 C2H2-type zinc finger
  580-602 Zinc finger, C2H2 type
  595-618 Zinc-finger double domain
  607-617 C2H2-type zinc finger
  608-630 C2H2-type zinc finger
  608-630 Zinc finger, C2H2 type
  623-645 Zinc-finger double domain
  635-660 C2H2-type zinc finger
  636-658 Zinc finger, C2H2 type
  636-658 C2H2-type zinc finger
  651-673 Zinc-finger double domain
  663-673 C2H2-type zinc finger
  664-686 Zinc finger, C2H2 type
  682-703 Zinc-finger double domain
  691-714 C2H2-type zinc finger
  692-714 C2H2-type zinc finger
  692-714 Zinc finger, C2H2 type
  706-730 Zinc-finger double domain
  720-742 Zinc finger, C2H2 type
  721-742 C2H2-type zinc finger
  735-758 Zinc-finger double domain
  747-770 C2H2-type zinc finger
  748-770 C2H2-type zinc finger
  748-770 Zinc finger, C2H2 type
Sequence: 
(in bold interface residues)		   1 MNKVEQKSQESVSFKDVTVGFTQEEWQHLDPSQRALYRDVMLENYSNLVSVGYCVHKPEV   60
  61 IFRLQQGEEPWKQEEEFPSQSFPVWTADHLKERSQENQSKHLWEVVFINNEMLTKEQGDV  120
 121 IGIPFNVDVSSFPSRKMFCQCDSCGMSFNTVSELVISKINYLGKKSDEFNACGKLLLNIK  180
 181 HDETHTQEKNEVLKNRNTLSHHEETLQHEKIQTLEHNFEYSICQETLLEKAVFNTQKREN  240
 241 AEENNCDYNEFGRTLCDSSSLLFHQISPSRDNHYEFSDCEKFLCVKSTLSKPHGVSMKHY  300
 301 DCGESGNNFRRKLCLSHLQKGDKGEKHFECNECGKAFWEKSHLTRHQRVHTGQKPFQCNE  360
 361 CEKAFWDKSNLTKHQRSHTGEKPFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGKT  420
 421 FCQKSDLTKHQRTHTGLKPYECYECGKSFRVTSHLKVHQRTHTGEKPFECLECGKSFSEK  480
 481 SNLTQHQRIHIGDKSYECNACGKTFYHKSLLTRHQIIHTGWKPYECYECGKTFCLKSDLT  540
 541 VHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHTGEKPYECHECGKIFYNKSYLTKHNR  600
 601 THTGEKPYECNECGKAFYQKSQLTQHQRIHIGEKPYKCNECGKAFCHKSALIVHQRTHTQ  660
 661 EKPYKCNECGKSFCVKSGLIFHERKHTGEKPYECNECGKFFRHKSSLTVHHRAHTGEKSC  720
 721 QCNECGKIFYRKSELAQHQRSHTGEKPYECNTCRKTFSQKSNLIVHQRRHIGENLMNEMD  780
 781 IRNFQPQVSLHNASEYSHCGESPDDILNVQ
Interface Residues: 338, 339, 341, 342, 345, 366, 367, 368, 369, 370, 373, 394, 395, 396, 397, 398, 400, 401, 403, 404, 407, 423, 424, 425, 426, 428, 429, 430, 433, 450, 451, 452, 453, 454, 456, 457, 478, 479, 480, 481, 482, 485, 507, 508, 509, 510, 513, 535, 536, 537, 538, 541, 544, 552, 563, 564, 565, 566, 568, 569, 575, 589, 590, 591, 592, 593, 594, 596, 597, 601, 618, 619, 620, 621, 622, 625, 647, 648, 649, 650, 651, 653, 674, 675, 678, 703, 705, 706, 709, 733, 759, 762, 765, 769
3D-footprint Homologues: 1tf3_A, 2i13_A, 6blw_A, 5und_A, 2gli_A, 7n5w_A, 8ssu_A, 1tf6_A, 6ml4_A, 5kkq_D, 5k5i_A, 8ssq_A, 7w1m_H, 8h9h_G, 7eyi_G, 3uk3_C, 6jnm_A, 8cuc_F, 1llm_D, 1mey_C, 7txc_E, 6e94_A, 6a57_A, 2jpa_A, 2wbs_A, 5kl3_A, 6wmi_A, 4m9v_C, 7ysf_A, 1ubd_C, 7y3l_A, 5yj3_D, 5v3j_F, 5yel_A, 2kmk_A, 4x9j_A, 8gn3_A, 5ei9_F, 1f2i_J, 1g2f_F, 2lt7_A, 6u9q_A, 2drp_D, 5k5l_F, 7y3m_I
Binding Motifs: ZNF33A_ChIP rYCTsGGCACyWTKGRrSRCYr
			
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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