Transcription Factor

Accessions: ETV1_DBD (HumanTF 1.0), ETV1_TF2 (HumanTF2 1.0)
Names: ETS translocation variant 1, Ets-related protein 81, ETV1, ETV1_HUMAN
Organisms: Homo sapiens
Libraries: HumanTF 1.0 1, HumanTF2 1.0 2
1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]
2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Uniprot: P50549
Notes: Ensembl ID: ENSG00000006468; DNA-binding domain sequence; TF family: ETS; Clone source: Megaman, Ensembl ID: ENSG00000006468; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013
Length: 126
Pfam Domains: 22-103 Ets-domain
Sequence:
(in bold interface residues)
1 MAIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVAR 60
61 RWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPL 120
121 LKTDME
Interface Residues: 62, 74, 75, 77, 78, 79, 81, 82, 96
3D-footprint Homologues: 6sjf_B, 8ee9_F, 4uno_A, 3jtg_A, 1dux_F, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 4iri_A, 1bc8_C, 4l18_B, 4lg0_B, 1yo5_C, 4bqa_A, 1awc_A
Binding Motifs: ETV1_DBD aCCGGAWrtr
FOXO1_ETV1 rsCGGAwGttkw
GCM1_ETV1 rtrsGGGCGGAwGkk
HOXB13_ETV1 rCCGGAAgTawwaAAa
HOXB2_ETV1 rCCGGAAATgr-
HOXD12_ETV1_1 rcCGGAAGTAATAAAm
HOXD12_ETV1_2 rsCGGAAGTCRTAAAw
POU2F1_ETV1 aCCGGATATGCAw
TEAD4_ETV1 acCGGAAaTrcc
TFAP4_ETV1 rsCGGAwgCAGsTGgk
Publications: Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed]

Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed]
Related annotations: PaperBLAST

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