Transcription Factor
| Accessions: | FOSL2_HUMAN (HOCOMOCO 10), P15408 (JASPAR 2024) |
| Names: | Fos-related antigen 2, FOSL2_HUMAN, FRA-2 |
| Organisms: | Homo sapiens |
| Libraries: | HOCOMOCO 10 1, JASPAR 2024 2 1 Kulakovskiy IV, Vorontsov IE, Yevshin IS, Soboleva AV, Kasianov AS, Ashoor H, Ba-Alawi W, Bajic VB, Medvedeva YA, Kolpakov FA, Makeev VJ. HOCOMOCO: expansion and enhancement of the collection of transcription factor binding sites models. Nucleic Acids Res : (2016). [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Length: | 326 |
| Pfam Domains: | 122-181 bZIP transcription factor 124-176 Basic region leucine zipper |
| Sequence: (in bold interface residues) | 1 MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQQKFRVDMPGSGSAFIPTINAITTSQDL 60 61 QWMVQPTVITSMSNPYPRSHPYSPLPGLASVPGHMALPRPGVIKTIGTTVGRRRRDEQLS 120 121 PEEEEKRRIRRERNKLAAAKCRNRRRELTEKLQAETEELEEEKSGLQKEIAELQKEKEKL 180 181 EFMLVAHGPVCKISPEERRSPPAPGLQPMRSGGGSVGAVVVKQEPLEEDSPSSSSAGLDK 240 241 AQRSVIKPISIAGGFYGEEPLHTPIVVTSTPAVTPGTSNLVFTYPSVLEQESPASPSESC 300 301 SKAHRRSSSSGDQSSDSLNSPTLLAL |
| Interface Residues: | 127, 130, 131, 134, 135, 137, 138, 141, 142, 145 |
| 3D-footprint Homologues: | 8k86_A, 4eot_A, 7x5e_E, 7x5e_F, 8k8c_A, 1skn_P, 2dgc_A |
| Binding Motifs: | MA0478.1 krrTGAsTCAb FOSL2_HUMAN.H10MO.A|M01140 rTGACTCAyyc MA1130.1 kkrTGAGTCAym MA1131.1 grTGACGTmAt MA0478.2 rrTGAsTCAb MA1130.2 rTGAGTCAy MA1131.2 rTGACGTmAt |
| Binding Sites: | MA0478.1.1 MA0478.1.10 / MA0478.1.7 / MA0478.1.8 / MA0478.1.9 MA0478.1.11 MA0478.1.12 MA0478.1.13 MA0478.1.14 MA0478.1.15 MA0478.1.16 MA0478.1.17 MA0478.1.18 MA0478.1.19 MA0478.1.2 MA0478.1.20 MA0478.1.3 MA0478.1.4 MA0478.1.5 MA0478.1.6 MA0478.2.1 MA0478.2.10 / MA0478.2.7 / MA0478.2.8 / MA0478.2.9 MA0478.2.11 MA0478.2.12 MA0478.2.13 MA0478.2.14 MA0478.2.15 MA0478.2.16 MA0478.2.17 MA0478.2.18 MA0478.2.19 MA0478.2.2 MA0478.2.20 MA0478.2.3 MA0478.2.4 MA0478.2.5 MA0478.2.6 |
| Publications: | Portales-Casamar E, Kirov S, Lim J, Lithwick S, Swanson M.I, Ticoll A, Snoddy J, Wasserman W.W. PAZAR: a framework for collection and dissemination of cis-regulatory sequence annotation. Genome biology 8:R207 (2007). [Pubmed] Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol : (2002). [Pubmed] |
| Related annotations: | PaperBLAST |
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