Transcription Factor
| Accessions: | T016864_1.02 (CISBP 1.02), Q18711 (JASPAR 2024) |
| Names: | mxl-3, T016864_1.02;, Q18711_CAEEL |
| Organisms: | Caenorhabditis elegans |
| Libraries: | CISBP 1.02 1, JASPAR 2024 2 1 Weirauch MT, Yang A, Albu M, Cote AG, Montenegro-Montero A, Drewe P, Najafabadi HS, Lambert SA, Mann I, Cook K, Zheng H, Goity A, van Bakel H, Lozano JC, Galli M, Lewsey MG, Huang E, Mukherjee T, Chen X, Reece-Hoyes JS, Govindarajan S, Shaulsky G, et al. Determination and inference of eukaryotic transcription factor sequence specificity. Cell. 2014 Sep 11;158(6):1431-43. doi: 10.1016/j.cell.2014.08.009. [Pubmed] 2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed] |
| Uniprot: | Q18711 |
| Notes: | experiment type:PBM, family:bHLH |
| Length: | 235 |
| Pfam Domains: | 48-99 Helix-loop-helix DNA-binding domain |
| Sequence: (in bold interface residues) | 1 MSAIVEDMYLLSSSMKMEKQFRKRHHSDSSDDDSSSPKSASPSMDDDRRAHHNELERRRR 60 61 DHIKDHFTILKDAIPLLDGEKSSRALILKRAVEFIHVMQTKLSSQGKAIEDLTRKNELLE 120 121 ERLLERESSGSPSSSRLPALAVSSSQMQLTMPIIPQMQNIAQLSQYPQQANIIAQSTNPA 180 181 QLDGLIALNNDAILALLGSFQSVSPSLLDSAPGTPPSGFYPCAFSPVDQQMAVKI |
| Interface Residues: | 49, 51, 52, 53, 55, 56, 59, 60, 84 |
| 3D-footprint Homologues: | 7z5k_B, 1an4_A, 7d8t_A, 4zpk_A, 7xi3_A, 5nj8_D, 7f2f_B, 5eyo_A, 5v0l_A, 1am9_A, 7rcu_E, 5gnj_I, 6g1l_A, 7ssa_L, 5i50_B |
| Binding Motifs: | PL0007.1 yrdAmCACGTGktymr M0227_1.02 sCACGTGt MA2176.1 cCACGTGg |
| Binding Sites: | MA2176.1.11 / MA2176.1.6 MA2176.1.18 MA2176.1.13 MA2176.1.15 MA2176.1.17 MA2176.1.16 MA2176.1.3 MA2176.1.12 / MA2176.1.5 MA2176.1.4 MA2176.1.1 / MA2176.1.10 MA2176.1.14 MA2176.1.19 / MA2176.1.20 MA2176.1.2 / MA2176.1.9 MA2176.1.7 MA2176.1.8 |
| Publications: | Grove C.A, De Masi F, Barrasa M.I, Newburger D.E, Alkema M.J, Bulyk M.L, Walhout A.J. A multiparameter network reveals extensive divergence between C. elegans bHLH transcription factors. Cell 138:314-27 (2009). [Pubmed] |
| Related annotations: | PaperBLAST |
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