Transcription Factor
| Accessions: | DLX2 (HT-SELEX2 May2017) |
| Names: | DLX2, ENSG00000115844 |
| Organisms: | Homo sapiens |
| Libraries: | HT-SELEX2 May2017 1 1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed] |
| Notes: | TF family: Homeodomain experiment: HT-SELEX Hamming distance: 1 cycle: 2, TF family: Homeodomain experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 2 |
| Length: | 186 |
| Pfam Domains: | 1-81 Homeobox protein distal-less-like N terminal 102-158 Homeobox domain |
| Sequence: (in bold interface residues) | 1 ESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLG 60 61 YTAAYTSYAPYGTSSSPANNEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRF 120 121 QKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCA 180 181 SPPVSA |
| Interface Residues: | 102, 103, 104, 105, 143, 144, 146, 147, 150, 151, 154, 155, 158 |
| 3D-footprint Homologues: | 5zjt_E, 2h1k_B, 1puf_A, 1fjl_B, 6a8r_A, 3cmy_A, 1ig7_A, 3d1n_M, 5zfz_A, 2lkx_A, 1nk2_P, 1zq3_P, 6m3d_C, 7q3o_C, 6es3_K, 2ld5_A, 3a01_E, 7psx_B, 1au7_A, 5hod_A, 3lnq_A, 2hdd_A, 1b72_A, 5jlw_D, 3rkq_B, 2r5y_A, 4xrs_G, 2hos_A, 4cyc_A, 1jgg_B, 5flv_I, 1e3o_C, 1le8_A, 7xrc_C, 2xsd_C, 4qtr_D, 1k61_B, 4xrm_B, 1puf_B, 1du0_A, 3l1p_A, 1o4x_A, 8g87_X |
| Binding Motifs: | DLX2_2 syAATTAy DLX2_4 syAATTAy DLX2_methyl_1 syAATTAt DLX2_methyl_3 syAATTAy |
| Related annotations: | PaperBLAST |
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