Transcription Factor

						

			
Accessions: 6jrp_A (3D-footprint 20231221), 6jrp_D (3D-footprint 20231221), 6jrp_G (3D-footprint 20231221), 6jrp_J (3D-footprint 20231221)

			
Names: CIC_HUMAN, Protein capicua homolog
Organisms: Homo sapiens
Libraries: 3D-footprint 20231221 1
1 Contreras-Moreira B. 3D-footprint: a database for the structural analysis of protein-DNA complexes. Nucleic acids research 38:D91-7 (2010). [Pubmed]
Uniprot: Q96RK0
Length: 74
Pfam Domains:      2-70 HMG (high mobility group) box
     3-61 Domain of unknown function (DUF1898)
Sequence: 
(in bold interface residues)		   1 HIRRPMNAFMIFSKRHRALVHQRHPNQDNRTVSKILGEWWYALGPKEKQKYHDLAFQVKE   60
  61 AHFKAHPDWKWCNK
Interface Residues: 4, 7, 9, 10, 13, 17, 20, 28, 29, 30, 31, 33, 71, 73
3D-footprint Homologues: 3tmm_A, 4y60_C, 2gzk_A, 1j5n_A, 6jrp_D, 2lef_A, 3u2b_C, 1o4x_B, 7m5w_A, 3f27_D, 4s2q_D, 1qrv_A, 1hry_A, 3tq6_B, 1ckt_A, 7zie_A
Binding Motifs: 6jrp_AD AATGAAArtTTTCAT
6jrp_D AATGAAA
6jrp_GJ ATGAAAatTTTCAT
Binding Sites: 6jrp_E
6jrp_F
6jrp_H
6jrp_I
			
Publications: Lee H, Song JJ. The crystal structure of Capicua HMG-box domain complexed with the ETV5-DNA and its implications for Capicua-mediated cancers. FEBS J 286:4951-4963 (2019). [Pubmed]
Related annotations: PaperBLAST

	
			


			

				

				
				
				
				

			

			

		

	
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