Transcription Factor
| Accessions: | ELF1_full (HumanTF 1.0), ELF1_TF2 (HumanTF2 1.0) |
| Names: | E74-like factor 1, ELF1, ELF1_HUMAN, ETS-related transcription factor Elf-1, E74-like factor 4, ELF4_HUMAN, ETS-related transcription factor Elf-4, Myeloid Elf-1-like factor |
| Organisms: | Homo sapiens |
| Libraries: | HumanTF 1.0 1, HumanTF2 1.0 2 1 Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] 2 Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Uniprot: | P32519 |
| Notes: | Ensembl ID: ENSG00000120690; Full protein sequence; TF family: ETS; Clone source: hORFeome, Ensembl ID: ENSG00000120690; Construct type: TF2(3xFLAG); TF family: ETS; Clone source: Jolma et al. 2013 |
| Length: | 596 |
| Pfam Domains: | 1-111 Transcription factor protein N terminal 184-267 Ets-domain |
| Sequence: (in bold interface residues) | 1 MAAVVQQNDLVFEFASNVMEDERQLGDPAIFPAVIVEHVPGADILNSYAGLACVEEPNDM 60 61 ITESSLDVAEEEIIDDDDDDITLTVEASCHDGDETIETIEAAEALLNMDSPGPMLDEKRI 120 121 NGIPEVMETQQVQEKYADSPGASSPEQPKRKKGRKTKPPRPDSPATTPNISVKKKNKDGK 180 181 GNTIYLWEFLLALLQDKATCPKYIKWTQREKGIFKLVDSKAVSRLWGKHKNKPDMNYETM 240 241 GRALRYYYQRGILAKVEGQRLVYQFKEMPKDLIYINDEDPSSSIESSDPSLSSSATSNRN 300 301 QTSRSRVSSSPGVKGGATTVLKPGNSKAAKPKDPVEVAQPSEVLRTVQPTQSPYPTQLFR 360 361 TVHVVQPVQAVPEGEAARTSTMQDETLNSSVQSIRTIQAPTQVPVVVSPRNQQLHTVTLQ 420 421 TVPLTTVIASTDPSAGTGSQKFILQAIPSSQPMTVLKENVMLQSQKAGSPPSIVLGPAQV 480 481 QQVLTSNVQTICNGTVSVASSPSFSATAPVVTFSPRSSQLVAHPPGTVITSVIKTQETKT 540 541 LTQEVEKKESEDHLKENTEKTEQQPQPYVMVVSSSNGFTSQVAMKQNELLEPNSF* |
| Interface Residues: | 238, 239, 241, 242, 243, 245, 246, 260, 427, 434, 446 |
| 3D-footprint Homologues: | 4uno_A, 3jtg_A, 3zp5_A, 7jsa_J, 4mhg_A, 2stt_A, 8ee9_F, 1dux_F, 4l18_B, 1awc_A, 4lg0_B, 1yo5_C, 4bqa_A, 1bc8_C, 4iri_A, 6fbc_A, 1tau_A |
| Binding Motifs: | ELF1_full AACCCGGAAGTr CEBPG_ELF1 TkrcghmAtwsMGGAAGt FOXJ2_ELF1_1 rtaaACmGGAAGwr FOXJ2_ELF1_2 rcAGAAAACCGAAwm FOXJ3_ELF1 rcarAAAACCGAAwmv FOXO1_ELF1_1 cagAAAACCGAAwm FOXO1_ELF1_2 kTGTTGCCGGAAgkk FOXO1_ELF1_2_3 rtmAACAGGAAgtd GCM1_ELF1_1 rkGcGGGCGGAaGtr GCM1_ELF1_2 kvCGGAArTGckGGt GCM1_ELF1_2_3 crCCCrCACGGAAGtr HOXB2_ELF1_1 smGGAAGTmrTta HOXB2_ELF1_2 ggymATtArsrwksmGGAAGtr HOXB2_ELF1_2_3 gymATyAgsgraksmGGAAGtr HOXB2_ELF1_2_3_4 TaATkrwyvMGGAAGtr HOXB2_ELF1_2_3_4_5 TrAtkrswrsmGGAAGtr MEIS1_ELF1 vTGmCGGAAgyr MYBL1_ELF1 amCCGGAACCGTTa TEAD4_ELF1_1 rgAATGCGGAAGtr TEAD4_ELF1_2 gGAATGCGGAAGtr |
| Publications: | Jolma A, Yan J, Whitington T, Toivonen J, Nitta KR, Rastas P, Morgunova E, Enge M, Taipale M, Wei G, Palin K, Vaquerizas JM, Vincentelli R, Luscombe NM, Hughes TR, Lemaire P, Ukkonen E, Kivioja T, Taipale J. DNA-Binding Specificities of Human Transcription Factors. Cell. 2013 Jan 17;152(1-2):327-39. [Pubmed] Jolma A, Yin Y, Nitta KR, Dave K, Popov A, Taipale M, Enge M, Kivioja T, Morgunova E, Taipale J. DNA-dependent formation of transcription factor pairs alters their binding specificity. Nature 527:384-8 (2015). [Pubmed] |
| Related annotations: | PaperBLAST |
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