Transcription Factor

Accessions: ZNF821 (HT-SELEX2 May2017), O75541 (JASPAR 2024)
Names: ENSG00000102984, ZNF821, ZN821_HUMAN
Organisms: Homo sapiens
Libraries: HT-SELEX2 May2017 1, JASPAR 2024 2
1 Yin Y, Morgunova E, Jolma A, Kaasinen E, Sahu B, Khund-Sayeed S, Das PK, Kivioja T, Dave K, Zhong F, Nitta KR, Taipale M, Popov A, Ginno PA, Domcke S, Yan J, Schübeler D, Vinson C, Taipale J. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Science : (2017). [Pubmed]
2 Rauluseviciute I, Riudavets-Puig R, Blanc-Mathieu R, Castro-Mondragon JA, Ferenc K, Kumar V, Lemma RB, Lucas J, Cheneby J, Baranasic D, Khan A, Fornes O, Gundersen S, Johansen M, Hovig E, Lenhard B, Sandelin A, Wasserman WW, Parcy F, Mathelier A. JASPAR 2024: 20th anniversary of the open-access database of transcription factor binding profiles. Nucleic Acids Res : (2023). [Pubmed]
Notes: TF family: Znf_C2H2 experiment: HT-SELEX Hamming distance: 1 cycle: 4, TF family: Znf_C2H2 experiment: Methyl-HT-SELEX Hamming distance: 1 cycle: 4
Length: 412
Pfam Domains: 150-172 Zinc finger, C2H2 type
Sequence:
(in bold interface residues)
1 MSRRKQTNPNKVHWDQVFAGLEEQARQAMMKTDFPGDLGSQRQAIQQLRDQDSSSSDSEG 60
61 DEEETTQDEVSSHTSEEDGGVVKVEKELENTEQPVGGNEVVEHEVTGNLNSDPLLELCQC 120
121 PLCQLDCGSREQLIAHVYQHTAAVVSAKSYMCPVCGRALSSPGSLGRHLLIHSEDQRSNC 180
181 AVCGARFTSHATFNSEKLPEVLNMESLPTVHNEGPSSAEGKDIAFSPPVYPAGILLVCNN 240
241 CAAYRKLLEAQTPSVRKWALRRQNEPLEVRLQRLERERTAKKSRRDNETPEEREVRRMRD 300
301 REAKRLQRMQETDEQRARRLQRDREAMRLKRANETPEKRQARLIREREAKRLKRRLEKMD 360
361 MMLRAQFGQDPSAMAALAAEMNFFQLPVSGVELDSQLLGKMAFEEQNSSSLH
Interface Residues: 96, 97, 99, 102, 106, 128, 129, 131, 132, 133, 134, 135, 136, 138, 139, 140, 141, 142, 145, 150, 160, 161, 162, 163, 164, 165, 166, 167, 168, 188, 189, 190, 191, 192, 298, 299, 301, 302, 305, 306, 319, 323, 324, 326, 327, 331, 342
3D-footprint Homologues: 8ssq_A, 7w1m_H, 8ssu_A, 5kkq_D, 8cuc_F, 1g2f_F, 8gn3_A, 4x9j_A, 1tf3_A, 6e94_A, 6ml4_A, 5v3j_F, 7ysf_A, 5kl3_A, 6blw_A, 5ei9_F, 6u9q_A, 4m9v_C, 2jpa_A, 2kmk_A, 7y3l_A, 7n5w_A, 6jnm_A, 7txc_E, 1f2i_J, 1ubd_C, 5k5i_A, 5yj3_D, 1llm_D, 8h9h_G, 2lt7_A, 7y3m_I, 6a57_A, 5d23_A
Binding Motifs: UN0237.1 / ZNF821_2 mgGACAGACrGACak
ZNF821_methyl_1 mGGACAGACGGACrk
UN0237.2 gGACAGACrGACa
Related annotations: PaperBLAST

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